NDRG2 - NDRG family member 2 Gene

Also Known as SYLD

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57447

About NDRG2

Cytogenetic location: 14q11.2 Genomic coordinates (GRCh38): 14:21,016,763-21,070,872 (from NCBI)

This gene has 77 transcripts (splice variants), 199 orthologues and 3 paralogues. Broad expression in salivary gland (RPKM 217.5), brain (RPKM 177.5) and 19 other tissues.

Summary

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that may play a role in neurite outgrowth. This gene may be involved in glioblastoma carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]

NDRG2 Products (27)

mRNA Protein Name
NM_001282211.2 NP_001269140.1 protein NDRG2 isoform c
NM_001282212.2 NP_001269141.1 protein NDRG2 isoform d
NM_001282213.2 NP_001269142.1 protein NDRG2 isoform b
NM_001282214.2 NP_001269143.1 protein NDRG2 isoform b
NM_001282215.2 NP_001269144.1 protein NDRG2 isoform e
NM_001282216.2 NP_001269145.1 protein NDRG2 isoform f
NM_001320329.2 NP_001307258.1 protein NDRG2 isoform a
NM_001354558.2 NP_001341487.1 protein NDRG2 isoform g
NM_001354559.2 NP_001341488.1 protein NDRG2 isoform a
NM_001354560.2 NP_001341489.1 protein NDRG2 isoform h
NM_001354561.2 NP_001341490.1 protein NDRG2 isoform b
NM_001354562.2 NP_001341491.1 protein NDRG2 isoform a
NM_001354564.2 NP_001341493.1 protein NDRG2 isoform i
NM_001354565.2 NP_001341494.1 protein NDRG2 isoform a
NM_001354566.1 NP_001341495.1 protein NDRG2 isoform a
NM_001354567.2 NP_001341496.1 protein NDRG2 isoform a
NM_001354568.2 NP_001341497.1 protein NDRG2 isoform b
NM_001354569.1 NP_001341498.1 protein NDRG2 isoform b
NM_001354570.2 NP_001341499.1 protein NDRG2 isoform a
NM_016250.3 NP_057334.1 protein NDRG2 isoform b
NM_201535.2 NP_963293.1 protein NDRG2 isoform a
NM_201536.2 NP_963294.1 protein NDRG2 isoform b
NM_201537.2 NP_963831.1 protein NDRG2 isoform a
NM_201538.2 NP_963832.1 protein NDRG2 isoform b
NM_201539.2 NP_963833.1 protein NDRG2 isoform a
NM_201540.2 NP_963834.1 protein NDRG2 isoform a
NM_201541.2 NP_963835.1 protein NDRG2 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21217774 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDRG2 Protein Structure

Ndr

Ndr: Ndr family (41 - 318)

  • 0
  • 100
  • 200
  • 300
  • 371 a.a.
Protein Preferred Names Protein Names

protein NDRG2

  • N-myc downstream regulator 2

NDRG2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83550 NDRG2 Antibody (YA3295) WB, IHC-F, IHC-P, ICC/IF, IP Mouse, Rat
HY-P83550A NDRG2 Antibody (YA3295)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Mouse, Rat

Related Diseases

Diseases Alias
Glioblastoma

  • Glioblastoma Multiforme

  • Gbm

  • Adult Glioblastoma Multiforme

  • Grade Iv Adult Astrocytic Tumor

  • Primary Glioblastoma Multiforme

  • Spongioblastoma Multiforme

  • Adult Glioblastoma

  • Primary Glioblastoma
Charcot-Marie-Tooth Disease, Type 4d

  • Charcot-Marie-Tooth Disease Type 4d

  • CMT4D

  • Hmsnl

  • Hmsn4d

  • Charcot-Marie-Tooth Neuropathy Type 4d

  • Hereditary Motor And Sensory Neuropathy Lom Type

  • Hmsn-Lom

  • Neuropathy, Hereditary Motor And Sensory, Lom Type

  • Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive, Type 4d

  • Charcot-Marie-Tooth Neuropathy, Type 4d

  • Autosomal Recessive Demyelinating Charcot-Marie-Tooth Disease Type 4d

  • Hmsn Lom Type

  • Hmsn, Lom Type

  • Hereditary Motor And Sensory Neuropathy, Lom Type

  • Charcot-Marie-Tooth Disease 4d

  • Charcot-Marie-Tooth Disease Demyelinating Autosomal Recessive 4d

  • Hereditary Motor And Sensory Neuropathy Ivd

  • Hmsn Ivd
Intracranial Meningioma

  • Meningioma
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P10359A TAT-QFNP12 acetate Inhibitor 95.90% Unkown
HY-100443 PX20606 Agonist / Unkown
HY-139418 PX20350 Agonist / Unkown
HY-P10359 TAT-QFNP12 Inhibitor / Unkown
HY-RS09115 NDRG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20061 Ndrg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26565 Ndrg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NDRG2 MGD MGI:1352498
Canis familiaris NDRG2 VGNC VGNC:43679
Rattus norvegicus NDRG2 RGD RGD:621874
Felis catus NDRG2 VGNC VGNC:63754
Macaca mulatta NDRG2 VGNC VGNC:74953
Bos taurus NDRG2 VGNC VGNC:50007
Others NDRG2 NCBI