ADGRB2 - adhesion G protein-coupled receptor B2 Gene

Also Known as BAI2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 576

About ADGRB2

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:31,727,117-31,764,340 (from NCBI)

This gene has 15 transcripts (splice variants), 199 orthologues and 42 paralogues. Biased expression in brain (RPKM 26.9), adrenal (RPKM 2.1) and 5 other tissues.

Summary

This gene encodes a a seven-span transmembrane protein that is thought to be a member of the Secretin Receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

ADGRB2 Products (3)

mRNA Protein Name
NM_001294335.2 NP_001281264.1 adhesion G protein-coupled receptor B2 isoform 1 preproprotein
NM_001294336.2 NP_001281265.1 adhesion G protein-coupled receptor B2 isoform 2 preproprotein
NM_001364857.2 NP_001351786.1 adhesion G protein-coupled receptor B2 isoform 3 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
28891236 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28891236 GOA
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
28891236 GOA
involved in calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
28891236 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
28891236 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRB2 Protein Structure

TSP_1

TSP_1: Thrombospondin type 1 domain (314 - 361)

TSP_1

TSP_1: Thrombospondin type 1 domain (369 - 416)

TSP_1

TSP_1: Thrombospondin type 1 domain (424 - 471)

TSP_1

TSP_1: Thrombospondin type 1 domain (479 - 527)

(606 - 863)

GPS

GPS: GPCR proteolysis site, GPS, motif (871 - 917)

7tm_2

7tm_2: 7 transmembrane receptor (Secretin family) (931 - 1198)

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  • 1585 a.a.
Protein Preferred Names Protein Names

adhesion G protein-coupled receptor B2

  • brain-specific angiogenesis inhibitor 2

Recombinant ADGRB2 Proteins

Cat. No. Product Name Accession Purity
HY-P79380 BAI2 Protein, Human (HEK293, hFc) O60241-3 (F21-D911) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Anal Carcinoma In Situ

  • Carcinoma In Situ Of Anal Canal

  • Carcinoma In Situ Of Anus

  • Anal Carcinoma Stage 0

  • Anal Intraepithelial Neoplasia Grade Iii

  • Intraepithelial Neoplasia Of Anal Canal, High Grade

  • Ain - [Anal Intraepithelial Neoplasia] High Grade
Vibratory Urticaria

  • Vibratory Angioedema

  • Dermodistortive Urticaria

  • VBU

  • Ddu

  • Angioedema, Vibratory
Polymicrogyria, Bilateral Frontoparietal

  • Bilateral Frontoparietal Polymicrogyria

  • BFPP

  • Cerebellar Ataxia With Neuronal Migration Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00346 ADGRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19763 Adgrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26260 Adgrb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ADGRB2 VGNC VGNC:37634
Felis catus ADGRB2 VGNC VGNC:69074
Mus musculus ADGRB2 MGD MGI:2451244
Bos taurus ADGRB2 VGNC VGNC:25659
Rattus norvegicus ADGRB2 RGD RGD:1309431
Macaca mulatta ADGRB2 VGNC VGNC:69598
Others ADGRB2 NCBI