PTPRCAP - protein tyrosine phosphatase receptor type C associated protein Gene
Also Known as LPAP; CD45-AP
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 5790
About PTPRCAP
Cytogenetic location: 11q13.2
Genomic coordinates (GRCh38): 11:67,435,510-67,437,682 (from NCBI)
This gene has 1 transcript (splice variant) and 88 orthologues. Biased expression in spleen (RPKM 58.4), lymph node (RPKM 46.1) and 9 other tissues.
Summary
The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine Phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein. [provided by RefSeq, Jul 2008]
PTPRCAP Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_005608.3 | NP_005599.1 | protein tyrosine phosphatase receptor type C-associated protein precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
11390434 | GOA |
EXP: Inferred from Experiment
IDA: Inferred from direct assay
IPI: Inferred from physical interaction
IMP: Inferred from mutant phenotype
IGI: Inferred from genetic interaction
IEP: Inferred from expression pattern
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
protein tyrosine phosphatase receptor type C-associated protein |
|
PTPRCAP Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PTPRCAP | Q14761 | DCDC2 | Homo sapiens | Q9UHG0 | 32296183 | |
|
Intra
|
PTPRCAP | Q14761 | DCDC2 | Homo sapiens | Q9UHG0 | 32296183 | |
|
Intra
|
PTPRCAP | Q14761 | DCDC2 | Homo sapiens | Q9UHG0 | 32296183 |
Cross: Cross-species interaction
Intra: Intraspecies interaction
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Gallbladder Squamous Cell Carcinoma |
|
Related Agents
- Pre-clinical Phase
Pre-clinical Phase
Bioactive Molecules
(1)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-RS11435 | PTPRCAP Human Pre-designed siRNA Set A | Pre-designed Set | / | Unkown |
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