Crlf2 - cytokine receptor-like factor 2 Gene

Also Known as CRLM2; Ly114; Tpte2; Tslpr

Species: Mus musculus

Gene Type: protein coding
Gene ID: 57914

Summary

Predicted to enable cytokine activity; cytokine binding activity; and cytokine receptor activity. Acts upstream of or within inflammatory response. Located in external side of plasma membrane. Is expressed in rib. Orthologous to human CRLF2 (cytokine receptor like factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Crlf2 Products (3)

mRNA Protein Name
NM_001164735.1 NP_001158207.1 cytokine receptor-like factor 2 isoform 1 precursor
NM_001310694.1 NP_001297623.1 cytokine receptor-like factor 2 isoform 3
NM_016715.4 NP_057924.3 cytokine receptor-like factor 2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24632570 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within T-helper 2 cell cytokine production IDA
IDA: Inferred from direct assay
16142237 MGI
acts upstream of or within immunoglobulin production involved in immunoglobulin-mediated immune response IDA
IDA: Inferred from direct assay
16142237 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
16142237 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
15488943 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytokine receptor-like factor 2

  • TSLP receptor

  • cytokine receptor-like molecule 2

  • lymphocyte antigen 114

  • thymic stromal lymphopoietin protein receptor

  • thymic stromal-derived lymphopoietin, receptor

  • transmembrane phosphoinositide 3-phosphatase and tensin homolog 2

  • type I cytokine rec

Recombinant Crlf2 Proteins

Cat. No. Product Name Accession Purity
HY-P70823 TSLP Receptor Protein, Mouse (HEK293, Fc) AAH23788.1 (A20-L233) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P70989 TSLP Receptor Protein, Mouse (HEK293, His) AAH23788.1 (A20-L233) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990767 Solrikitug Inhibitor 99.28% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151902 SJ988497 Degrader 99.03% Unkown
HY-RS03187 CRLF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18809 Crlf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25299 Crlf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991720 Tepilukimig Inhibitor 95.57% Unkown
HY-P991467 RG-7258 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Crlf2 NCBI NCBI:64109