Trem1 - triggering receptor expressed on myeloid cells 1 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58217

Summary

Predicted to enable scaffold protein binding activity. Acts upstream of or within neutrophil chemotaxis; neutrophil extravasation; and neutrophil-mediated killing of gram-negative bacterium. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Is expressed in bladder and renal vasculature. Human ortholog(s) of this gene implicated in Bacterial pneumonia; Bacterial sepsis; malaria; and myocardial infarction. Orthologous to human TREM1 (triggering receptor expressed on myeloid cells 1). [provided by Alliance of Genome Resources, Apr 2022]

Trem1 Products (2)

mRNA Protein Name
NM_001347399.1 NP_001334328.1 triggering receptor expressed on myeloid cells 1 isoform 2 precursor
NM_021406.5 NP_067381.1 triggering receptor expressed on myeloid cells 1 isoform 1 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within chemokine production IGI
IGI: Inferred from genetic interaction
23241959 MGI
acts upstream of or within cytokine production IGI
IGI: Inferred from genetic interaction
23241959 MGI
acts upstream of or within cytokine production involved in immune response IGI
IGI: Inferred from genetic interaction
23241959 MGI
acts upstream of or within neutrophil chemotaxis IGI
IGI: Inferred from genetic interaction
23241959 MGI
acts upstream of or within neutrophil extravasation IGI
IGI: Inferred from genetic interaction
23241959 MGI
acts upstream of or within neutrophil migration IGI
IGI: Inferred from genetic interaction
23241959 MGI
acts upstream of or within neutrophil-mediated killing of gram-negative bacterium IGI
IGI: Inferred from genetic interaction
23241959 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

triggering receptor expressed on myeloid cells 1

  • triggering receptor expressed in monocytes 1

Recombinant Trem1 Proteins

Cat. No. Product Name Accession Purity
HY-P70716 TREM-1 Protein, Mouse (HEK293, His) Q9JKE2 (A21-S202) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-P3211A Nangibotide TFA Inhibitor 99.86% Phase 2
HY-P3211 Nangibotide Inhibitor 98.53% Phase 2
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990650 PY159 Inhibitor 98.44% Phase 1

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157122 VJDT Inhibitor 99.68% Unkown
HY-174369 TREM2 agonist-3 99.39% Unkown
HY-P10086 TREM-1 inhibitory peptide GF9 Inhibitor 99.41% Unkown
HY-P11077 LR-17 Inhibitor 97.52% Unkown
HY-182702 As48 / Unkown
HY-P10938 LP17 (human) Inhibitor 90.14% Unkown
HY-RS15002 TREM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16560 Trem1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10088 Mouse TREM-1 SCHOOL peptide, control Control / Unkown
HY-RS22992 Trem1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trem1 NCBI NCBI:54210