Apln - apelin Gene

Also Known as Apel

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58812

Summary

Enables apelin receptor binding activity and identical protein binding activity. Involved in several processes, including apelin receptor signaling pathway; positive regulation of peptide hormone secretion; and regulation of blood circulation. Located in extracellular space and perinuclear region of cytoplasm. Used to study congestive heart failure. Biomarker of colitis; congestive heart failure; hypertension; and obesity. Orthologous to human APLN (apelin). [provided by Alliance of Genome Resources, Apr 2022]

Apln Products (1)

mRNA Protein Name
NM_031612.3 NP_113800.1 apelin preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables apelin receptor binding IDA
IDA: Inferred from direct assay
11336787 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
15486224 RGD
Biological Process GO Annotation Evidence References Source
involved in apelin receptor signaling pathway IDA
IDA: Inferred from direct assay
11359874 RGD
involved in drinking behavior IMP
IMP: Inferred from mutant phenotype
10617103 RGD
involved in feeding behavior IMP
IMP: Inferred from mutant phenotype
14642423 RGD
involved in negative regulation of blood pressure IDA
IDA: Inferred from direct assay
15486224 RGD
involved in negative regulation of blood pressure IMP
IMP: Inferred from mutant phenotype
10617103 RGD
involved in negative regulation of systemic arterial blood pressure IDA
IDA: Inferred from direct assay
12798955 RGD
involved in negative regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
17318790 RGD
involved in positive regulation of G protein-coupled receptor internalization IDA
IDA: Inferred from direct assay
11359874 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
14670994 RGD
involved in positive regulation of corticotropin secretion IMP
IMP: Inferred from mutant phenotype
16896162 RGD
involved in positive regulation of corticotropin-releasing hormone secretion IMP
IMP: Inferred from mutant phenotype
15541902 RGD
involved in positive regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
26611206 RGD
involved in positive regulation of heart rate IDA
IDA: Inferred from direct assay
12798955 RGD
involved in positive regulation of heat generation IMP
IMP: Inferred from mutant phenotype
15541902 RGD
involved in positive regulation of phosphorylation IMP
IMP: Inferred from mutant phenotype
16556853 RGD
involved in regulation of body fluid levels IMP
IMP: Inferred from mutant phenotype
12787050 RGD
involved in regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
17055480 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
16674982 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15166125 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

apelin

  • APJ endogenous ligand

  • apelin, AGTRL1 ligand

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00822 APLN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18461 Apln Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24942 Apln Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Apln NCBI NCBI:8862