Nt5e - 5' nucleotidase, ecto Gene

Also Known as Nt5; CD73

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58813

About Nt5e

Primary_assembly 8: 89,270,696-89,314,881 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 249 orthologues and is associated with 6 phenotypes. Biased expression in Liver (RPKM 474.8), Kidney (RPKM 312.5) and 9 other tissues.

Summary

Enables 5'-nucleotidase activity and ferrous iron binding activity. Involved in several processes, including nucleobase-containing small molecule metabolic process; positive regulation of lipid biosynthetic process; and response to aluminum ion. Located in cell surface and synaptic membrane. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in hereditary arterial and articular multiple calcification syndrome. Orthologous to human NT5E (5'-nucleotidase ecto). [provided by Alliance of Genome Resources, Apr 2022]

Nt5e Products (1)

mRNA Protein Name
NM_021576.2 NP_067587.2 5'-nucleotidase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 5'-nucleotidase activity IDA
IDA: Inferred from direct assay
1770988 RGD
enables ferrous iron binding IDA
IDA: Inferred from direct assay
11935367 RGD
Biological Process GO Annotation Evidence References Source
involved in AMP catabolic process IDA
IDA: Inferred from direct assay
21414400 RGD
involved in AMP catabolic process IMP
IMP: Inferred from mutant phenotype
30269308 RGD
involved in adenosine biosynthetic process IMP
IMP: Inferred from mutant phenotype
30269308 RGD
involved in adenosine metabolic process IDA
IDA: Inferred from direct assay
12675911 RGD
involved in positive regulation of lipid biosynthetic process IEP
IEP: Inferred from expression pattern
21372807 RGD
involved in response to aluminum ion IEP
IEP: Inferred from expression pattern
17686601 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
21627568 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
1770988 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
21414400 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Nt5e Protein Structure

MPP_CD73_N

MPP_CD73_N: cd07409 (30 - 311)

5_nucleotid_C

5_nucleotid_C: pfam02872 (340 - 514)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 576 a.a.
Protein Preferred Names Protein Names

5'-nucleotidase

  • 5'-NT

  • ecto-5'-nucleotidase

Recombinant Nt5e Proteins

Cat. No. Product Name Accession Purity
HY-P7449 CD73/5'-Nucleotidase Protein, Rat (HEK293, His) P21588 (W29-K549) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (5)
Cat. No. Product Name Effect
Purity Phase
HY-P991009 Mavrostobart 98.50% Phase 2
HY-P991332 JAB-BX102 Inhibitor / Phase 2
HY-P991330 BMS-986179 Inhibitor / Phase 2
HY-P990771 Uprevstobart 96.98% Phase 1
HY-P991443 IPH5301 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09612 NT5E Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09613 Nt5e Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09614 Nt5e Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990900 Ansipastobart 96.259% Unkown
HY-P991331 BC-010 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nt5e NCBI NCBI:4907