Sh2b3 - SH2B adaptor protein 3 Gene

Also Known as Lnk

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 58838

Summary

Enables phosphate ion binding activity. Involved in negative regulation of sprouting angiogenesis and regulation of regulatory T cell differentiation. Predicted to be active in plasma membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in essential thrombocythemia; familial erythrocytosis 1; and myelofibrosis. Orthologous to human SH2B3 (SH2B adaptor protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Sh2b3 Products (1)

mRNA Protein Name
NM_001402348.1 NP_001389277.1 SH2B adapter protein 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables phosphate ion binding IDA
IDA: Inferred from direct assay
8524815 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
8524815 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of sprouting angiogenesis IMP
IMP: Inferred from mutant phenotype
25628389 RGD
involved in regulation of regulatory T cell differentiation IMP
IMP: Inferred from mutant phenotype
25776069 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

SH2B adapter protein 3

  • linker of T-cell receptor pathways

  • lymphocyte adapter protein

  • lymphocyte-specific adapter protein Lnk

  • signal transduction protein Lnk

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12820 SH2B3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22804 Sh2b3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29318 Sh2b3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sh2b3 NCBI NCBI:10019