Smpd3 - sphingomyelin phosphodiesterase 3, neutral Gene

Also Known as fro; nSMase2; 4631433G07Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58994

Summary

Enables identical protein binding activity; neutral sphingomyelin phosphodiesterase activity; and phospholipid binding activity. Involved in sphingomyelin metabolic process. Acts upstream of or within several processes, including animal organ development; enzyme linked receptor protein signaling pathway; and sphingolipid metabolic process. Located in Golgi cis cisterna and plasma membrane. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and skeleton. Used to study hypopituitarism; osteogenesis imperfecta; osteogenesis imperfecta type 2; and osteogenesis imperfecta type 3. Orthologous to human SMPD3 (sphingomyelin phosphodiesterase 3). [provided by Alliance of Genome Resources, Apr 2022]

Smpd3 Products (1)

mRNA Protein Name
NM_021491.4 NP_067466.1 sphingomyelin phosphodiesterase 3

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
25287744 MGI
enables neutral sphingomyelin phosphodiesterase activity IDA
IDA: Inferred from direct assay
16025116 MGI
enables phosphatidic acid binding IDA
IDA: Inferred from direct assay
21550973 MGI
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
21550973 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20080539 MGI
enables sphingomyelin phosphodiesterase activity IDA
IDA: Inferred from direct assay
10823942 MGI
enables sphingomyelin phosphodiesterase activity IMP
IMP: Inferred from mutant phenotype
15764706 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
24505141 MGI
acts upstream of or within DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
23651497 MGI
acts upstream of or within G1 to G0 transition IMP
IMP: Inferred from mutant phenotype
23046545 MGI
acts upstream of or within bone development IMP
IMP: Inferred from mutant phenotype
27325675 MGI
acts upstream of or within bone growth IMP
IMP: Inferred from mutant phenotype
17626887 MGI
acts upstream of or within bone mineralization IDA
IDA: Inferred from direct assay
21788370 MGI
acts upstream of or within bone mineralization IMP
IMP: Inferred from mutant phenotype
21788370 MGI
acts upstream of or within cartilage development IDA
IDA: Inferred from direct assay
27325675 MGI
acts upstream of or within cartilage development IMP
IMP: Inferred from mutant phenotype
17591962 MGI
acts upstream of or within cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
23651497 MGI
acts upstream of or within cellular response to magnesium ion IDA
IDA: Inferred from direct assay
23973266 MGI
acts upstream of or within cellular response to oxidised low-density lipoprotein particle stimulus IMP
IMP: Inferred from mutant phenotype
20352118 MGI
acts upstream of or within cellular response to peptide IMP
IMP: Inferred from mutant phenotype
27325675 MGI
acts upstream of or within cellular response to reactive oxygen species IMP
IMP: Inferred from mutant phenotype
17561096 MGI
acts upstream of or within cellular response to redox state IMP
IMP: Inferred from mutant phenotype
25287744 MGI
acts upstream of or within cellular response to tumor necrosis factor IMP
IMP: Inferred from mutant phenotype
16025116 MGI
acts upstream of or within ceramide metabolic process IMP
IMP: Inferred from mutant phenotype
22383528 MGI
acts upstream of or within chondrocyte development IMP
IMP: Inferred from mutant phenotype
17591962 MGI
acts upstream of or within chondrocyte development involved in endochondral bone morphogenesis IMP
IMP: Inferred from mutant phenotype
21788370 MGI
acts upstream of or within collagen metabolic process IMP
IMP: Inferred from mutant phenotype
22910579 MGI
acts upstream of or within dentinogenesis IMP
IMP: Inferred from mutant phenotype
16025116 MGI
acts upstream of or within endochondral ossification IMP
IMP: Inferred from mutant phenotype
17591962 MGI
acts upstream of or within extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
22910579 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within lung alveolus development IMP
IMP: Inferred from mutant phenotype
22945695 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
22945695 MGI
acts upstream of or within mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
20352118 MGI
acts upstream of or within multicellular organism growth IDA
IDA: Inferred from direct assay
24585429 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
24585429 MGI
acts upstream of or within negative regulation of hyaluronan biosynthetic process IMP
IMP: Inferred from mutant phenotype
22383528 MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
24505141 MGI
acts upstream of or within ossification IMP
IMP: Inferred from mutant phenotype
16025116 MGI
acts upstream of or within peptide hormone secretion IMP
IMP: Inferred from mutant phenotype
15764706 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
23651497 MGI
acts upstream of or within polysaccharide transport IMP
IMP: Inferred from mutant phenotype
22383528 MGI
acts upstream of or within positive regulation of mitotic nuclear division IGI
IGI: Inferred from genetic interaction
23651497 MGI
acts upstream of or within positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
17561096 MGI
acts upstream of or within regulation of cartilage development IMP
IMP: Inferred from mutant phenotype
24505141 MGI
acts upstream of or within regulation of hyaluronan biosynthetic process IMP
IMP: Inferred from mutant phenotype
22383528 MGI
acts upstream of or within regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
28377412 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
22383528 MGI
acts upstream of or within respiratory system development IMP
IMP: Inferred from mutant phenotype
22945695 MGI
acts upstream of or within signal transduction IMP
IMP: Inferred from mutant phenotype
17561096 MGI
acts upstream of or within skeletal system development IDA
IDA: Inferred from direct assay
24585429 MGI
acts upstream of or within skeletal system development IMP
IMP: Inferred from mutant phenotype
17591962 MGI
acts upstream of or within sphingolipid mediated signaling pathway IDA
IDA: Inferred from direct assay
23651497 MGI
acts upstream of or within sphingolipid metabolic process IMP
IMP: Inferred from mutant phenotype
22945695 MGI
acts upstream of or within sphingomyelin catabolic process IMP
IMP: Inferred from mutant phenotype
23973266 MGI
acts upstream of or within sphingomyelin metabolic process IDA
IDA: Inferred from direct assay
10823942 MGI
involved in sphingomyelin metabolic process IDA
IDA: Inferred from direct assay
21550973 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
10823942 MGI
located in Golgi cis cisterna IDA
IDA: Inferred from direct assay
15764706 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
21550973 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sphingomyelin phosphodiesterase 3

  • nSMase-2

  • neutral sphingomyelinase 2

  • neutral sphingomyelinase II

Smpd3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Smpd3 Q9JJY3 HSPD1 Homo sapiens P10809
Anti Bait CoIP
23840630
Cross
Smpd3 Q9JJY3 HSPD1 Homo sapiens P10809
PLA
23840630
Cross
Smpd3 Q9JJY3 EED Homo sapiens O75530
Y2H
20080539
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13449 SMPD3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21047 Smpd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27565 Smpd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smpd3 NCBI NCBI:55512