Med12 - mediator complex subunit 12 Gene

Also Known as Mopa; OPA-1; 230kDa; Tnrc11; Trap230

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59024

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including Wnt signaling pathway; chordate embryonic development; and glial cell development. Part of mediator complex. Is expressed in brain. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12). [provided by Alliance of Genome Resources, Apr 2022]

Med12 Products (1)

mRNA Protein Name
NM_021521.2 NP_067496.2 mediator of RNA polymerase II transcription subunit 12

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
23575864 MGI
enables chromatin binding IDA
IDA: Inferred from direct assay
20720539 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20720539 MGI
enables transcription coactivator activity IGI
IGI: Inferred from genetic interaction
23575864 MGI
enables transcription factor binding IPI
IPI: Inferred from physical interaction
23575864 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within Schwann cell development IMP
IMP: Inferred from mutant phenotype
23575864 MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway IMP
IMP: Inferred from mutant phenotype
20630950 MGI
acts upstream of or within axis elongation involved in somitogenesis IMP
IMP: Inferred from mutant phenotype
20630950 MGI
acts upstream of or within embryonic brain development IMP
IMP: Inferred from mutant phenotype
20589884 MGI
acts upstream of or within embryonic neurocranium morphogenesis IMP
IMP: Inferred from mutant phenotype
20589884 MGI
acts upstream of or within embryonic organ development IMP
IMP: Inferred from mutant phenotype
20589884 MGI
acts upstream of or within endoderm development IMP
IMP: Inferred from mutant phenotype
20589884 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
20630950 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
20630950 MGI
acts upstream of or within neural tube development IMP
IMP: Inferred from mutant phenotype
20589884 MGI
acts upstream of or within oligodendrocyte development IMP
IMP: Inferred from mutant phenotype
23575864 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
20589884 MGI
acts upstream of or within somatic stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
20720539 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
20589884 MGI
acts upstream of or within spinal cord development IMP
IMP: Inferred from mutant phenotype
20589884 MGI
Cellular Component GO Annotation Evidence References Source
part of mediator complex IDA
IDA: Inferred from direct assay
15340084 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mediator of RNA polymerase II transcription subunit 12

  • OPA-containing protein 1

  • mediator of RNA polymerase II transcription, subunit 12 homolog

  • thyroid hormone receptor-associated protein complex 230 kDa component

  • trinucleotide repeat containing 11 (THR-associated protein)

  • trinucleotide repeat containing

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114965 TP-064 Inhibitor 99.29% Unkown
HY-100360 MS049 Inhibitor 98.0% Unkown
HY-RS08281 MED12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-100360A MS049 dihydrochloride Inhibitor / Unkown
HY-RS08282 MED12L Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18290 Med12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24768 Med12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Med12 NCBI NCBI:9968