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Cat. No.: HY-100360A

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MS049 dihydrochloride

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

MS049 dihydrochloride is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC₅₀s of 34 nM and 43 nM, respectively. MS049 dihydrochloride reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 dihydrochloride is not toxic and does not affect the growth of HEK293 cells.

For research use only. We do not sell to patients.

CAS No.: 2095432-59-8
Formula: C₁₅H₂₆Cl₂N₂O
Molecular Weight:321.29

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

MS049 dihydrochloride Chemical Structure

CAS No.: 2095432-59-8

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Publications (1)
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Biological Activity

Description

All Histone Methyltransferase Isoforms :

In Vitro

MS049 dihydrochloride (0.1-10 μM; 20 hours) reduces the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC₅₀=0.97±0.05 μM)^[1].
MS049 dihydrochloride (0.1-100 μM; 72 hours) inhibits endogenous PRMT4 methyltransferase activity in a concentration dependent manner resulting in reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC₅₀=1.4±0.1 μM) in HEK293 cells^[1].
MS049 dihydrochloride is selective for PRMT4 and PRMT6 over a broad range of epigenetic modifiers, including other PRMTs, PKMTs, DNMTs, KDMs, and methyllysine/methylarginine reader proteins, and non-epigenetic targets^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

HEK293 cells
Concentration:

0.1, 1, 10 μM
Incubation Time:

20 hours
Result:

Reduced the H3R2me2a mark in HEK293 cells in a concentration dependent manner (IC₅₀=0.97±0.05 μM).

Western Blot Analysis^[1]

Cell Line:

HEK293 cells
Concentration:

0.1, 1, 10, 100 μM
Incubation Time:

72 hours
Result:

Reduced levels of cellular asymmetric arginine dimethylation of Med12 (Med12-Rme2a, IC₅₀=1.4±0.1 μM) in HEK293 cells.

Chemical Information

CAS No. 2095432-59-8
Molecular Weight 321.29
Formula C₁₅H₂₆Cl₂N₂O
SMILES

CNCCN1CCC(OCC2=CC=CC=C2)CC1.[H]Cl.[H]Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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Nat Commun

Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]

2026 Feb 12;17(1):1214. PMID: 41680175

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shen Y et al. Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6. J Med Chem. 2016 Oct 13;59(19):9124-9139. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MS049 dihydrochloride

1 Cited Publications

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Biological Activity
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Publications (1)
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MS049 dihydrochloride

Publications Citing Use of MedChemExpress (MCE) MS049 dihydrochloride

All Histone Methyltransferase Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

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Help & FAQs

MS049 dihydrochloride Related Classifications

HY-100360A Related Classifications