Pnkp - polynucleotide kinase 3'- phosphatase Gene

Also Known as PNK; 1810009G08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59047

Summary

Enables ubiquitin ligase-substrate adaptor activity. Involved in cellular response to DNA damage stimulus and protein K63-linked ubiquitination. Part of SCF ubiquitin Ligase complex. Is active in site of double-strand break. Is expressed in cerebellum; cerebral cortex; liver; and spleen. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2 and microcephaly, seizures, and developmental delay. Orthologous to human PNKP (polynucleotide kinase 3'-phosphatase). [provided by Alliance of Genome Resources, Apr 2022]

Pnkp Products (4)

mRNA Protein Name
NM_001290764.1 NP_001277693.1 bifunctional polynucleotide phosphatase/kinase isoform a
NM_001290766.1 NP_001277695.1 bifunctional polynucleotide phosphatase/kinase isoform b
NM_001290767.1 NP_001277696.1 bifunctional polynucleotide phosphatase/kinase isoform c
NM_021549.3 NP_067524.2 bifunctional polynucleotide phosphatase/kinase isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
26774286 MGI
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
26774286 MGI
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
26774286 MGI
Cellular Component GO Annotation Evidence References Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
26774286 MGI
is active in site of double-strand break IDA
IDA: Inferred from direct assay
26774286 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional polynucleotide phosphatase/kinase

  • DNA 5'-kinase/3'-phosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-135782A iso-ADP ribose TEA 99.97% Unkown
HY-135782 iso-ADP ribose / Unkown
HY-RS10778 PNKP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19631 Pnkp Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26126 Pnkp Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnkp NCBI NCBI:11284