PNKP - polynucleotide kinase 3'-phosphatase Gene

Also Known as PNK; AOA4; MCSZ; CMT2B2; EIEE10

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11284

About PNKP

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,861,204-49,867,576 (from NCBI)

This gene has 31 transcripts (splice variants), 188 orthologues and is associated with 7 phenotypes. Ubiquitous expression in spleen (RPKM 18.2), adrenal (RPKM 13.4) and 25 other tissues.

Summary

This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]

PNKP Products (1)

mRNA	Protein	Name
NM_007254.4	NP_009185.2	bifunctional polynucleotide phosphatase/kinase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity	IDA IDA: Inferred from direct assay	10446193	GOA
enables polynucleotide 3'-phosphatase activity	IDA IDA: Inferred from direct assay	10446192	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15385968	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA ligation involved in DNA repair	IDA IDA: Inferred from direct assay	15385968	GOA
involved in DNA repair	IGI IGI: Inferred from genetic interaction	10446192	GOA
involved in double-strand break repair via nonhomologous end joining	IDA IDA: Inferred from direct assay	15385968	GOA
involved in negative regulation of protein ADP-ribosylation	IMP IMP: Inferred from mutant phenotype	28002403	GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining	IMP IMP: Inferred from mutant phenotype	12032095	GOA
acts upstream of or within positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	21531765	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	10446192	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	10446193	GOA
is active in site of double-strand break	IDA IDA: Inferred from direct assay	28453785	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PNKP Protein Structure

PNK3P

AAA_33

0
100
200
300
400
521 a.a.

Protein Preferred Names	Protein Names
bifunctional polynucleotide phosphatase/kinase	DNA 5'-kinase/3'-phosphatase

PNKP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PNKP	Q96T60	PNMA5	Homo sapiens	Q96PV4	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	PNMA5	Homo sapiens	Q96PV4	Y2H Array	32296183
Intra	PNKP	Q96T60	ZBTB14	Homo sapiens	O43829	Y2H Array	25416956
Intra	PNKP	Q96T60	ZBTB14	Homo sapiens	O43829	Y2H Array	32296183
Intra	PNKP	Q96T60	ZBTB14	Homo sapiens	O43829	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	ZBTB14	Homo sapiens	O43829	Validated Y2H	25416956
Intra	PNKP	Q96T60	SP4	Homo sapiens	Q02446	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	SP4	Homo sapiens	Q02446	Y2H Array	32296183
Intra	PNKP	Q96T60	CCDC43	Homo sapiens	Q86WV7	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	CCDC43	Homo sapiens	Q86WV7	Y2H Array	32296183
Intra	PNKP	Q96T60	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	PNKP	Q96T60	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	SNX2	Homo sapiens	O60749	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	SNX2	Homo sapiens	O60749	Y2H Array	32296183
Intra	PNKP	Q96T60	PSTPIP1	Homo sapiens	O43586	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	PSTPIP1	Homo sapiens	O43586	Y2H Array	32296183
Intra	PNKP	Q96T60	RPRM	Homo sapiens	Q9NS64	Validated Y2H	32296183
Intra	PNKP	Q96T60	RPRM	Homo sapiens	Q9NS64	Y2H Array	32296183
Intra	PNKP	Q96T60	RPRM	Homo sapiens	Q9NS64	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	PNKP	Q96T60	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	SYNGR3	Homo sapiens	O43761	Y2H Array	32296183
Intra	PNKP	Q96T60	SYNGR3	Homo sapiens	O43761	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	MGST2	Homo sapiens	Q99735	Validated Y2H	32296183
Intra	PNKP	Q96T60	MGST2	Homo sapiens	Q99735	Y2H Array	32296183
Intra	PNKP	Q96T60	MGST2	Homo sapiens	Q99735	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	IKZF1	Homo sapiens	Q13422-7	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	IKZF1	Homo sapiens	Q13422-7	Y2H Array	32296183
Intra	PNKP	Q96T60	CAMK2B	Homo sapiens	Q13554-3	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	CAMK2B	Homo sapiens	Q13554-3	Y2H Array	32296183
Intra	PNKP	Q96T60	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
Intra	PNKP	Q96T60	CCDC14	Homo sapiens	Q49A88-3	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	CCDC14	Homo sapiens	Q49A88-3	Y2H Array	32296183
Intra	PNKP	Q96T60	SYNGR1	Homo sapiens	O43759-2	Y2H Array	32296183
Intra	PNKP	Q96T60	SYNGR1	Homo sapiens	O43759-2	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	PNKP	Q96T60	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	TBC1D1	Homo sapiens	Q86TI0	Y2H Array	32296183
Intra	PNKP	Q96T60	TBC1D1	Homo sapiens	Q86TI0	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	FOXO3	Homo sapiens	O43524	Pull Down	25609649
Intra	PNKP	Q96T60	COL17A1	Homo sapiens	Q9UMD9	Validated Y2H	32296183
Intra	PNKP	Q96T60	COL17A1	Homo sapiens	Q9UMD9	Y2H Array	32296183
Intra	PNKP	Q96T60	COL17A1	Homo sapiens	Q9UMD9	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	KANK2	Homo sapiens	Q63ZY3	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	KANK2	Homo sapiens	Q63ZY3	Y2H Array	32296183
Intra	PNKP	Q96T60	SFT2D1	Homo sapiens	Q8WV19	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	SFT2D1	Homo sapiens	Q8WV19	Y2H Array	32296183
Intra	PNKP	Q96T60	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	PNKP	Q96T60	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	PNKP	Q96T60	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	PNKP	Q96T60	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	PNKP	Q96T60	TNIP1	Homo sapiens	Q15025	Validated Y2H	25416956
Intra	PNKP	Q96T60	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	TNIP1	Homo sapiens	Q15025	Y2H Array	25416956
Intra	PNKP	Q96T60	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	PNKP	Q96T60	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	25416956
Intra	PNKP	Q96T60	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	PNKP	Q96T60	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	PNKP	Q96T60	FADS6	Homo sapiens	Q8N9I5	Y2H Array	32296183
Intra	PNKP	Q96T60	FADS6	Homo sapiens	Q8N9I5	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	XRCC4	Homo sapiens	Q13426	Anti Bait CoIP	15385968
Intra	PNKP	Q96T60	XRCC4	Homo sapiens	Q13426	Experimental Interac	15385968
Intra	PNKP	Q96T60	XRCC4	Homo sapiens	Q13426	Anti Bait CoIP	17353931
Intra	PNKP	Q96T60	XRCC4	Homo sapiens	Q13426	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	XRCC4	Homo sapiens	Q13426	BRET	38225382
Intra	PNKP	Q96T60	XRCC4	Homo sapiens	Q13426	ITC	15385968
Intra	PNKP	Q96T60	XRCC4	Homo sapiens	Q13426	Y2H Array	32296183
Intra	PNKP	Q96T60	DVL3	Homo sapiens	Q92997	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	DVL3	Homo sapiens	Q92997	Y2H Array	32296183
Intra	PNKP	Q96T60	KLHL12	Homo sapiens	Q53G59	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	KLHL12	Homo sapiens	Q53G59	Y2H Array	32296183
Intra	PNKP	Q96T60	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	PNKP	Q96T60	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	PNKP	Q96T60	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	TRIM37	Homo sapiens	O94972	Y2H Array	32296183
Intra	PNKP	Q96T60	TRIM37	Homo sapiens	O94972	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	IKZF1	Homo sapiens	Q13422	Y2H Prey Pooling	25416956
Intra	PNKP	Q96T60	MSANTD4	Homo sapiens	Q8NCY6	Y2H Array	32296183
Intra	PNKP	Q96T60	MSANTD4	Homo sapiens	Q8NCY6	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	PNKP	Q96T60	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	PNKP	Q96T60	CACFD1	Homo sapiens	Q9UGQ2	Validated Y2H	32296183
Intra	PNKP	Q96T60	CACFD1	Homo sapiens	Q9UGQ2	Y2H Array	32296183
Intra	PNKP	Q96T60	CACFD1	Homo sapiens	Q9UGQ2	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	SYP	Homo sapiens	P08247	Y2H Array	32296183
Intra	PNKP	Q96T60	SYP	Homo sapiens	P08247	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	CNTROB	Homo sapiens	Q8N137	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	CNTROB	Homo sapiens	Q8N137	Y2H Array	32296183
Intra	PNKP	Q96T60	XRCC1	Homo sapiens	P18887	Anti Bait CoIP	17353931
Intra	PNKP	Q96T60	ZNF639	Homo sapiens	Q9UID6	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	ZNF639	Homo sapiens	Q9UID6	Y2H Array	32296183
Intra	PNKP	Q96T60	ZNF639	Homo sapiens	Q9UID6	Validated Y2H	25416956
Intra	PNKP	Q96T60	ZNF639	Homo sapiens	Q9UID6	Validated Y2H	32296183
Intra	PNKP	Q96T60	TARBP2	Homo sapiens	Q15633	Y2H Prey Pooling	32296183
Intra	PNKP	Q96T60	TARBP2	Homo sapiens	Q15633	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PNKP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71620	PNKP Protein, Human (His-SUMO)	Q96T60-1 (M1-G521)	≥ 90%, as determined by reducing SDS-PAGE.

PNKP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83422	PNKP Antibody (YA3167)	WB, IHC-P, IP	Human
HY-P83422A	PNKP Antibody (YA3167)(PBS only)	WB, IHC-P, IP	Human

Related Diseases

Diseases	Alias
Ataxia-Oculomotor Apraxia 4	AOA4 Ataxia-Oculomotor Apraxia Type 4 Ataxia - Oculomotor Apraxia Type 4 Ataxia With Oculomotor Apraxia Type 4 Ataxia-Oculomotor Apraxia-4 Ataxia-Oculomotor Apraxia, Type 4
Charcot-Marie-Tooth Disease, Axonal, Type 2b2	Charcot-Marie-Tooth Disease Type 2b2 CMT2B2 Arcmt2b Charcot-Marie-Tooth Disease, Type 2b2 Ar-Cmt2b2 Autosomal Recessive Axonal Charcot-Marie-Tooth Disease Type 2b2 Autosomal Recessive Axonal Cmt4c3 Charcot-Marie-Tooth Disease Neuronal Type 2b2 Charcot-Marie-Tooth Neuropathy Type 2b2 Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2b2 Charcot-Marie-Tooth Disease, Neuronal, Type 2b2 Charcot-Marie-Tooth Neuropathy, Type 2b2 Charcot-Marie-Tooth Disease 2b2 Charcot-Marie-Tooth Disease Axonal Autosomal Recessive B2 Charcot-Marie-Tooth Disease Axonal Type 2b2
Microcephaly, Seizures, And Developmental Delay	MCSZ Developmental And Epileptic Encephalopathy 10 Epileptic Encephalopathy, Early Infantile, 10 Eiee10 Dee10 Early Infantile Epileptic Encephalopathy 10
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder
Developmental And Epileptic Encephalopathy 12	Epileptic Encephalopathy, Early Infantile, 12 DEE12 Eiee12 Early Infantile Epileptic Encephalopathy 12 Developmental And Epileptic Encephalopathy, 12 Encephalopathy, Epileptic, Early Infantile, Type 12
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Early Infantile Epileptic Encephalopathy	Early Infantile Epileptic Encephalopathy With Burst-Suppression Early Infantile Epileptic Encephalopathy With Suppression Bursts Eiee Early Infantile Epileptic Encephalopathy With Suppression-Bursts Ohtahara Syndrome Encephalopathy, Epileptic, Early Infantile
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia	Aoa1 Ataxia-Telangiectasia-Like Disorder EAOH Eoca-Ha Ataxia With Oculomotor Apraxia Type 1 Ataxia-Oculomotor Apraxia 1 Ataxia-Oculomotor Apraxia Syndrome AOA Ataxia-Telangiectasia-Like Syndrome Ataxia-Oculomotor Apraxia Type 1 Ataxia With Oculomotor Apraxia Cerebellar Ataxia, Early-Onset, With Hypoalbuminemia Early-Onset Ataxia With Oculomotor Apraxia And Hypoalbuminemia Early-Onset Cerebellar Ataxia With Hypoalbuminemia Adult Onset Ataxia With Oculomotor Apraxia Early-Onset Ataxia With Ocular Motor Apraxia And Hypoalbuminemia Scan2 Scar1 Spinocerebellar Ataxia With Axonal Neuropathy Type 2 Spinocerebellar Ataxia, Recessive, Non-Friedreich Type 1 Atld Ataxia Early-Onset With Oculomotor Apraxia And Hypoalbuminemia Cerebellar Ataxia Early-Onset With Hypoalbuminemia Ataxia-Oculomotor Apraxia Spinocerebellar Ataxia, Autosomal Recessive 1
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Apraxia	Apraxias Dyspraxia
Oculomotor Apraxia
Spinocerebellar Ataxia Type 1 With Axonal Neuropathy	Scan1 Spinocerebellar Ataxia With Axonal Neuropathy Type 1 Autosomal Recessive Spinocerebellar Ataxia With Axonal Neuropathy Scan1, Tdp1-Related Spinocerebellar Ataxia With Axonal Neuropathy Spinocerebellar Ataxia Autosomal Recessive With Axonal Neuropathy Spinocerebellar Ataxia With Axonal Neuropathy Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy Ataxia, Spinocerebellar, Autosomal Recessive With Axonal Neuropathy
Spinocerebellar Ataxia, Autosomal Recessive 26	SCAR26 Autosomal Recessive Spinocerebellar Ataxia 26 Spinocerebellar Ataxia, Autosomal Recessive, 26
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Spinocerebellar Ataxia, Autosomal Recessive 23	SCAR23 Autosomal Recessive Spinocerebellar Ataxia 23 Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Tud Deficiency Autosomal Recessive Cerebellar Ataxia - Epilepsy - Intellectual Disability Syndrome Due To Tud Deficiency Spinocerebellar Ataxia Autosomal Recessive Type 23 Spinocerebellar Ataxia, Autosomal Recessive, 23 Ataxia, Spinocerebellar, Autosomal Recessive, Type 23
Ataxia-Oculomotor Apraxia 3	Ataxia With Oculomotor Apraxia Type 3 AOA3 Aaxia-Oculomotor Apraxia-3 Ataxia-Oculomotor Apraxia, Type 3
Developmental And Epileptic Encephalopathy 8	DEE8 Epileptic Encephalopathy, Early Infantile, 8 Eiee8 Hyperekplexia And Epilepsy Developmental And Epileptic Encephalopathy, 8 Early Infantile Epileptic Encephalopathy 8 Hyperekplexia-Epilepsy Syndrome Hyperekplexia With Epilepsy Startle Disease With Epilepsy Encephalopathy, Epileptic, Early Infantile, Type 8
Pilocytic Astrocytoma Of Cerebellum	Cerebellar Pilocytic Astrocytoma
Lig4 Syndrome	Dna Ligase Iv Deficiency Ligase 4 Syndrome LIG4S
Ataxia-Telangiectasia	Ataxia Telangiectasia Louis-Bar Syndrome AT At1 Ataxia-Telangiectasia Syndrome Ataxia - Telangiectasia Variant Boder-Sedgwick Syndrome Louis Bar Syndrome Cerebello-Oculocutaneous Telangiectasia Immunodeficiency With Ataxia Telangiectasia A-T Ataxia Telangiectasia Syndrome Atm Telangiectasia, Cerebello-Oculocutaneous Ataxia-Telangiectasia Variant
Cerebellar Astrocytoma	Astrocytoma Of Cerebellum
Usher Syndrome, Type If	Usher Syndrome Type 1f USH1F Usher Syndrome, Type 1f Usher Syndrome Type If Usher Syndrome 1f Usher'S Syndrome Type 1f
Charcot-Marie-Tooth Disease	Cmt Hmsn Hereditary Motor And Sensory Neuropathy Pma Cmt - Charcot-Marie-Tooth Disease Charcot Marie Tooth Disease Charcot-Marie-Tooth Hereditary Neuropathy Charcot-Marie-Tooth Syndrome Peroneal Muscular Atrophy Hereditary Motor And Sensory Neuropathies
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2	Aoa2 Ataxia With Oculomotor Apraxia Type 2 Scar1 SCAN2 Ataxia-Oculomotor Apraxia 2 Ataxia-Ocular Apraxia 2 Ataxia-Oculomotor Apraxia Type 2 Scan 2 Spinocerebellar Ataxia With Axonal Neuropathy Type 2 Spinocerebellar Ataxia, Autosomal Recessive 1, Formerly Scar1, Formerly Autosomal Recessive Spinocerebellar Ataxia-1 Spinocerebellar Ataxia, Autosomal Recessive, 1 Ataxia-Ocular Apraxia-2 Spinocerebellar Ataxia, Autosomal Recessive 1
Autosomal Recessive Cerebellar Ataxia	Arca
Autosomal Dominant Cerebellar Ataxia	Spinocerebellar Ataxia Adca Pierre Marie Cerebellar Ataxia Ataxia, Spinocerebellar Sca Autosomal Dominant Spinocerebellar Ataxia Spinocerebellar Ataxias
Hereditary Ataxia	Sca Spinocerebellar Ataxia Ataxias Hereditary Ataxias, Hereditary
Cerebellar Disease	Cerebellar Diseases Cerebellar Dysfunction Cerebellar Abnormality Cerebellar Disorders
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Developmental And Epileptic Encephalopathy	Encephalopathy, Developmental And Epileptic
West Syndrome	Infantile Spasms Infantile Spasms Syndrome Infantile Spasm X-Linked Infantile Spasm Syndrome X-Linked Infantile Spasms Epileptic Encephalopathy, Early Infantile, 1 Is Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg West'S Syndrome Spasms, Infantile Is -[Infantile Spasm] Salaam Spasm Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-135782A	iso-ADP ribose TEA		99.97%	Unkown
HY-135782	iso-ADP ribose		/	Unkown
HY-RS10778	PNKP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19631	Pnkp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26126	Pnkp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PNKP	VGNC	VGNC:44743
Felis catus	PNKP	VGNC	VGNC:97559
Macaca mulatta	PNKP	VGNC	VGNC:76196
Mus musculus	PNKP	MGD	MGI:1891698
Bos taurus	PNKP	VGNC	VGNC:33081
Rattus norvegicus	PNKP	RGD	RGD:1303331
Others	PNKP	NCBI