Tpm3 - tropomyosin 3, gamma Gene

Also Known as TMnm; Tpm5; Tm5NM; Tpm-5; hTMnm; TM30nm; Trop-5; hTM30nm; gamma-TM

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59069

Summary

Enables actin filament binding activity. Predicted to be involved in actin filament organization and muscle contraction. Located in cleavage furrow; cytoskeleton; and growth cone. Is expressed in coelomic epithelium of testis; ovary; and primary sex cord. Human ortholog(s) of this gene implicated in congenital fiber-type disproportion and nemaline myopathy 1. Orthologous to human TPM3 (tropomyosin 3). [provided by Alliance of Genome Resources, Apr 2022]

Tpm3 Products (7)

mRNA Protein Name
NM_001253738.1 NP_001240667.1 tropomyosin alpha-3 chain isoform Tpm3.1cy
NM_001253740.1 NP_001240669.1 tropomyosin alpha-3 chain isoform Tpm3.2cy
NM_001271764.2 NP_001258693.1 tropomyosin alpha-3 chain isoform Tpm3.5cy
NM_001293748.1 NP_001280677.2 tropomyosin alpha-3 chain isoform Tpm3.12st
NM_001293749.1 NP_001280678.1 tropomyosin alpha-3 chain isoform Tpm3.4cy
NM_001357581.1 NP_001344510.1 tropomyosin alpha-3 chain isoform Tpm3.3cy
NM_022314.3 NP_071709.3 tropomyosin alpha-3 chain isoform Tpm3.13cy

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
16765662 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
Cellular Component GO Annotation Evidence References Source
located in cleavage furrow IDA
IDA: Inferred from direct assay
9473354 MGI
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
9473354 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
16765662 MGI
located in growth cone IDA
IDA: Inferred from direct assay
15888546 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
15888546 MGI
located in podosome IDA
IDA: Inferred from direct assay
16765662 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tropomyosin alpha-3 chain

  • gamma-tropomyosin

  • skalphaTM.2

  • tropomyosin 5

  • tropomyosin-3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-137465 CG428 Degrader 98.26% Phase 2

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-124689 TR-100 Inhibitor 99.0% Unkown
HY-157542 CG428-NEG Control 97.6% Unkown
HY-131244 ALK-IN-9 Inhibitor / Unkown
HY-175271 JWJ-01-378 / Unkown
HY-RS14938 TPM3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-164514 NMS-P626 Inhibitor / Unkown
HY-RS18503 Tpm3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24985 Tpm3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tpm3 NCBI NCBI:7170