Ntrk1 - neurotrophic receptor tyrosine kinase 1 Gene

Rattus norvegicus

Also known as Trk

Gene ID: 59109 | Gene type: protein coding

About Ntrk1

Primary_assembly 2: 173,236,963-173,253,770 reverse strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 200 orthologues, 54 paralogues and is associated with 46 phenotypes. Biased expression in Adrenal (RPKM 13.6), Brain (RPKM 6.2) and 6 other tissues.

Summary

Enables several functions, including GPI-linked Ephrin Receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of programmed cell death. Acts upstream of or within cellular response to growth factor stimulus and protein autophosphorylation. Located in several cellular components, including dendrite; endosome; and neuronal cell body. Part of protein-containing complex. Used to study glaucoma and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk1 Products(1)

mRNA	Protein	Name
NM_021589.1	NP_067600.1	high affinity nerve growth factor receptor precursor

Ntrk1 Protein Structure

LRR_1

LRR_8

LRR_1

TPKR_C2

IgI_TrKABC_d5

PKc_like

0
200
400
600
799 a.a.

Protein Preferred Names

Protein Names

high affinity nerve growth factor receptor

TrkA neurotrophin receptor	neurotrophic tyrosine kinase, receptor, type 1
p140-TrkA	slow nerve growth factor receptor
trk-A	trkA proto-oncogene receptor
tropomyosin-related kinase A

Recombinant Ntrk1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73459	TrkA Protein, Rat (HEK293, Fc)	P35739 (M1-P418)	≥95%
HY-P73460	TrkA Protein, Rat (HEK293, His)	P35739 (A33-P418)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131003	Taletrectinib	Inhibitor	99.78%	Phase 2
HY-131003A	Taletrectinib free base	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-144451	TRK-IN-12	Inhibitor	/	Unkown
HY-156086	TRK-IN-24	Inhibitor	/	Unkown
HY-RS09628	NTRK1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS09629	Ntrk1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS09630	Ntrk1 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk1	NCBI	NCBI:4914
Canis familiaris	Ntrk1	NCBI	NCBI:490404
Mus musculus	Ntrk1	NCBI	NCBI:18211
Leporidae	Ntrk1	NCBI

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