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Ntrk1 - neurotrophic receptor tyrosine kinase 1 Gene

Also Known as Trk

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 59109

About Ntrk1

Primary_assembly 2: 173,236,963-173,253,770 reverse strand.mRatBN7.2:CM026975.1

This gene has 4 transcripts (splice variants), 200 orthologues, 54 paralogues and is associated with 46 phenotypes. Biased expression in Adrenal (RPKM 13.6), Brain (RPKM 6.2) and 6 other tissues.

Summary

Enables several functions, including GPI-linked Ephrin Receptor activity; nerve growth factor binding activity; and neurotrophin p75 receptor binding activity. Involved in several processes, including detection of stimulus involved in sensory perception of pain; nervous system development; and regulation of programmed cell death. Acts upstream of or within cellular response to growth factor stimulus and protein autophosphorylation. Located in several cellular components, including dendrite; endosome; and neuronal cell body. Part of protein-containing complex. Used to study glaucoma and myofascial pain syndrome. Biomarker of several diseases, including colitis; diabetic neuropathy; glaucoma; periodontitis; and retinal detachment. Human ortholog(s) of this gene implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Orthologous to human NTRK1 (neurotrophic receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk1 Products (1)

mRNA	Protein	Name
NM_021589.1	NP_067600.1	high affinity nerve growth factor receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GPI-linked ephrin receptor activity	IDA IDA: Inferred from direct assay	19036963	RGD
enables kinase binding	IPI IPI: Inferred from physical interaction	10679771	RGD
enables nerve growth factor binding	IDA IDA: Inferred from direct assay	9753156	RGD
enables neurotrophin p75 receptor binding	IPI IPI: Inferred from physical interaction	9753156	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10691301	RGD
enables protein tyrosine kinase activity	IDA IDA: Inferred from direct assay	19029245	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in Sertoli cell development	IMP IMP: Inferred from mutant phenotype	18660385	RGD
involved in axon guidance	IMP IMP: Inferred from mutant phenotype	18344912	RGD
acts upstream of or within cellular response to growth factor stimulus	IDA IDA: Inferred from direct assay	19029245	RGD
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	17724123	RGD
involved in cellular response to nicotine	IDA IDA: Inferred from direct assay	16280603	RGD
involved in detection of mechanical stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	20351485	RGD
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	20351485	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	18440710	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	19146958	RGD
involved in nerve growth factor signaling pathway	IDA IDA: Inferred from direct assay	17724123	RGD
involved in olfactory nerve development	IEP IEP: Inferred from expression pattern	8778281	RGD
involved in positive regulation of programmed cell death	IDA IDA: Inferred from direct assay	20811452	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	19036963	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	21550171	RGD
involved in programmed cell death involved in cell development	IDA IDA: Inferred from direct assay	20811452	RGD
acts upstream of or within protein autophosphorylation	IDA IDA: Inferred from direct assay	19029245	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	21456016	RGD
involved in response to electrical stimulus	IDA IDA: Inferred from direct assay	19596387	RGD
involved in response to hydrostatic pressure	IEP IEP: Inferred from expression pattern	18817846	RGD
involved in response to nicotine	IDA IDA: Inferred from direct assay	20056136	RGD
involved in response to nutrient levels	IDA IDA: Inferred from direct assay	17582385	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	20059802	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	1315318	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	11134589	RGD
located in cell surface	IDA IDA: Inferred from direct assay	16280603	RGD
located in dendrite	IDA IDA: Inferred from direct assay	11134589	RGD
located in early endosome	IDA IDA: Inferred from direct assay	17724123	RGD
located in late endosome	IDA IDA: Inferred from direct assay	17724123	RGD
located in mitochondrion	IDA IDA: Inferred from direct assay	22138126	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	18395621	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	17724123	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	17724123	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	26446845	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntrk1 Protein Structure

LRR_1

LRR_8

LRR_1

TPKR_C2

IgI_TrKABC_d5

PKc_like

0
200
400
600
799 a.a.

Protein Preferred Names	Protein Names
high affinity nerve growth factor receptor	TrkA neurotrophin receptor neurotrophic tyrosine kinase, receptor, type 1 p140-TrkA slow nerve growth factor receptor trk-A trkA proto-oncogene receptor tropomyosin-related kinase A

Recombinant Ntrk1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73459	TrkA Protein, Rat (HEK293, Fc)	P35739-1 (A33-P418)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73460	TrkA Protein, Rat (HEK293, His)	P35739-1 (A33-P418)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131003	Taletrectinib	Inhibitor	99.63%	Unkown

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-131003A	Taletrectinib free base	Inhibitor	/	Unkown
HY-101977A	(R,S)-Selitrectinib	Inhibitor	/	Unkown
HY-144451	TRK-IN-12	Inhibitor	/	Unkown
HY-156086	TRK-IN-24	Inhibitor	/	Unkown
HY-180172	TRK-IN-33		/	Unkown
HY-181052	PROTAC NTRK1 degrader-1	Degrader	/	Unkown
HY-185545	NTRK1-ligand-1	Ligand	/	Unkown
HY-E70869	TRKA(NTRK1) Recombinant Human Active Protein Kinase		/	Unkown
HY-RS09628	NTRK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09629	Ntrk1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09630	Ntrk1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185546	CRBN ligand-900 Gly		/	Unkown
HY-D3447	LPd peroxida probe-2		99.17%	Unkown
HY-W1115186	CRBN ligand-900		/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990589	GBR-900		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk1	NCBI	NCBI:4914