Ago2 - argonaute RISC catalytic component 2 Gene

Also Known as Eif2c2; eIF2C 2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59117

Summary

Predicted to enable several functions, including endoribonuclease activity, producing 5'-phosphomonoesters; nucleic acid binding activity; and protein C-terminus binding activity. Involved in negative regulation of amyloid precursor protein biosynthetic process. Located in mitochondrion. Orthologous to human AGO2 (argonaute RISC catalytic component 2). [provided by Alliance of Genome Resources, Apr 2022]

Ago2 Products (1)

mRNA Protein Name
NM_001408918.1 NP_001395847.1 protein argonaute-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables Hsp70 protein binding IDA
IDA: Inferred from direct assay
11553639 RGD
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
11553639 RGD
enables RISC complex binding IDA
IDA: Inferred from direct assay
30404558 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
24882364 RGD
Biological Process GO Annotation Evidence Verweise Source
involved in cellular response to calcium ion IEP
IEP: Inferred from expression pattern
28404816 RGD
involved in negative regulation of amyloid precursor protein biosynthetic process IMP
IMP: Inferred from mutant phenotype
20395292 RGD
involved in positive regulation of post-transcriptional gene silencing by RNA IMP
IMP: Inferred from mutant phenotype
15147961 RGD
involved in regulation of mRNA stability IMP
IMP: Inferred from mutant phenotype
26846850 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
26944283 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
21969601 RGD
involved in response to morphine IEP
IEP: Inferred from expression pattern
23927484 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
27029769 RGD
Cellular Component GO Annotation Evidence Verweise Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
11553639 RGD
located in P granule IDA
IDA: Inferred from direct assay
27029769 RGD
part of RISC complex IDA
IDA: Inferred from direct assay
30404558 RGD
located in chromatoid body IDA
IDA: Inferred from direct assay
27029769 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
27029769 RGD
located in cytoplasmic stress granule IDA
IDA: Inferred from direct assay
30404558 RGD
located in cytosol IDA
IDA: Inferred from direct assay
27029769 RGD
located in dendrite IDA
IDA: Inferred from direct assay
28404816 RGD
located in membrane IDA
IDA: Inferred from direct assay
11553639 RGD
located in mitochondrion IDA
IDA: Inferred from direct assay
22518031 RGD
located in pi-body IDA
IDA: Inferred from direct assay
27029769 RGD
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
23041308 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein argonaute-2

  • argonaute 2, RISC catalytic component

  • argonaute2

  • eukaryotic translation initiation factor 2C 2

  • golgi ER protein 95 kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-119024 BCI-137 99.84% Unkown
HY-RS00453 AGO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17683 Ago2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24144 Ago2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ago2 NCBI NCBI:27161