Syt7 - synaptotagmin 7 Gene

Also Known as SytVII

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59267

Summary

Enables several functions, including calcium ion binding activity; calcium-dependent phospholipid binding activity; and syntaxin binding activity. Involved in calcium ion regulated lysosome exocytosis; plasma membrane repair; and regulation of secretion by cell. Located in dense core granule; lysosome; and plasma membrane. Is active in hippocampal mossy fiber to CA3 synapse. Is integral component of presynaptic membrane. Orthologous to human SYT7 (synaptotagmin 7). [provided by Alliance of Genome Resources, Apr 2022]

Syt7 Products (7)

mRNA Protein Name
NM_001398614.1 NP_001385543.1 synaptotagmin-7 isoform 1
NM_001398615.1 NP_001385544.1 synaptotagmin-7 isoform 2
NM_001398616.1 NP_001385545.1 synaptotagmin-7 isoform 3
NM_001398617.1 NP_001385546.1 synaptotagmin-7 isoform 4
NM_001398618.1 NP_001385547.1 synaptotagmin-7 isoform 5
NM_001398620.1 NP_001385549.1 synaptotagmin-7 isoform 6
NM_021659.3 NP_067691.1 synaptotagmin-7 isoform 7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IMP
IMP: Inferred from mutant phenotype
11395007 RGD
enables calcium-dependent phospholipid binding IDA
IDA: Inferred from direct assay
7791877 RGD
enables clathrin binding IDA
IDA: Inferred from direct assay
7791877 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
26437117 RGD
enables syntaxin binding IDA
IDA: Inferred from direct assay
7791877 RGD
Biological Process GO Annotation Evidence References Source
involved in calcium ion regulated lysosome exocytosis IDA
IDA: Inferred from direct assay
10725327 RGD
involved in calcium-ion regulated exocytosis IDA
IDA: Inferred from direct assay
11395007 RGD
involved in plasma membrane repair IDA
IDA: Inferred from direct assay
11511344 RGD
involved in positive regulation of calcium ion-dependent exocytosis IDA
IDA: Inferred from direct assay
21551071 RGD
involved in regulation of calcium ion-dependent exocytosis IMP
IMP: Inferred from mutant phenotype
10725327 RGD
involved in regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
17709608 RGD
involved in regulation of synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
14532108 RGD
involved in regulation of synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
14532108 RGD
Cellular Component GO Annotation Evidence References Source
located in dense core granule IDA
IDA: Inferred from direct assay
20016973 RGD
is active in hippocampal mossy fiber to CA3 synapse IDA
IDA: Inferred from direct assay
11395007 RGD
located in lysosome IDA
IDA: Inferred from direct assay
10725327 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
11395007 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptotagmin-7

  • protein Syt7

  • synaptotagmin VII

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14119 SYT7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20823 Syt7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27337 Syt7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Syt7 NCBI NCBI:9066