RBMS1 - RNA binding motif single stranded interacting protein 1 Gene

Also Known as YC1; MSSP; SCR2; HCC-4; MSSP-1; MSSP-2; MSSP-3; C2orf12

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5937

About RBMS1

Cytogenetic location: 2q24.2 Genomic coordinates (GRCh38): 2:160,272,151-160,493,807 (from NCBI)

This gene has 14 transcripts (splice variants), 270 orthologues and 24 paralogues. Ubiquitous expression in placenta (RPKM 34.9), endometrium (RPKM 27.3) and 24 other tissues.

Summary

This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and Apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]

RBMS1 Products (2)

mRNA Protein Name
NM_002897.5 NP_002888.1 RNA-binding motif, single-stranded-interacting protein 1 isoform c
NM_016836.4 NP_058520.1 RNA-binding motif, single-stranded-interacting protein 1 isoform a

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10869558 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBMS1 Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (64 - 124)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (143 - 207)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

RNA-binding motif, single-stranded-interacting protein 1

  • c-myc gene single strand binding protein 2

RBMS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RBMS1 P29558 TFCP2 Homo sapiens Q12800
Validated Y2H
25416956
Intra
RBMS1 P29558 TFCP2 Homo sapiens Q12800
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Diffuse Glomerulonephritis

  • Glomerulonephritis Diffuse
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations

  • MCPH2

  • Primary Autosomal Recessive Microcephaly 2 With Or Without Cortical Malformations

  • Microcephaly, Primary Autosomal Recessive, 2
Epidermolysis Bullosa, Junctional 1b, Severe

  • Epidermolysis Bullosa, Junctional, Herlitz Type

  • Epidermolysis Bullosa Letalis

  • JEB1B

  • Epidermolysis Bullosa Junctionalis, Herlitz Type

  • Jeb-Herlitz Type

  • Herlitz-Pearson-Type Epidermolysis Bullosa

  • Junctional Epidermolysis Bullosa Herlitz Type

  • Jeb-H

  • Junctional Epidermolysis Bullosa Generalisata Gravis

  • Junctional Epidermolysis Bullosa, Herlitz-Pearson Type

  • Epidermolysis Bullosa, Junctional, Generalized Severe

  • Epidermolysis Bullosa, Junctional, Herlitz-Pearson Type

  • Herlitz Type Epidermolysis Bullosa Junctionalis

  • Severe Generalized Junctional Epidermolysis Bullosa

  • Junctional Epidermolysis Bullosa, Herlitz Type

  • Severe Generalized Jeb

  • Epidermolysis Letalis

  • Junctional Epidermolysis Bullosa Gravis

  • Junctional Epidermolysis Bullosa Herlitz-Pearson Type

  • Herlitz Disease
Hemolytic Uremic Syndrome, Atypical 1

  • Atypical Hemolytic-Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1

  • Atypical Hemolytic Uremic Syndrome

  • Hemolytic Uremic Syndrome, Atypical, Susceptibility To

  • Ahus

  • AHUS1

  • Hemolytic-Uremic Syndrome

  • Ahus 1

  • Ahus, Susceptibility To, 1

  • Hemolytic Uremic Syndrome, Atypical

  • Non-Shiga-Like Toxin-Associated Hus

  • Non-Stx-Hus

  • Nonenteropathic Hus

  • Atypical Hus

  • Shiga Toxin-Associated Hemolytic Uremic Syndrome

  • D+ Hus

  • Ehec-Hus

  • Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli

  • Hemolytic Uremic Syndrome With Diarrhea

  • Stec-Hus

  • Shiga-Like Toxin-Associated Hus

  • Stx-Hus

  • Typical Hus

  • Typical Hemolytic Uremic Syndrome

  • Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies

  • Atypical Hus With Anti-Factor H Antibodies

  • Ahus With Anti-Factor H Antibodies

  • Ahus With Neutralizing Autoantibodies Against Factor H

  • Hemolytic Uremic Syndrome Atypical 1

  • Atypical Hemolytic Uremic Syndrome With H Factor Anomaly

  • D Hus

  • Hemolytic-Uremic Syndrome Without Diarrhea

  • Hemolytic-Uremic Syndrome, Atypical, Type 1

  • Hemolytic Uremic Syndrome, Typical
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159649A (1R)-BMS-986408 Inhibitor 99.03% Unkown
HY-N15826 RBM1-151 Substrate / Unkown
HY-RS11760 RBMS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RBMS1 RGD RGD:1307777
Mus musculus RBMS1 MGD MGI:1861774
Bos taurus RBMS1 VGNC VGNC:33809
Felis catus RBMS1 VGNC VGNC:69268
Macaca mulatta RBMS1 VGNC VGNC:76686
Canis familiaris RBMS1 VGNC VGNC:45427
Others RBMS1 NCBI