Grm8 - glutamate metabotropic receptor 8 Gene

Also Known as Glur8; mGlur; Gprc1h; Mglur8; mGluR8b

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 60590

About Grm8

Primary_assembly 4: 55,805,955-56,730,831 reverse strand.mRatBN7.2:CM026977.1

This gene has 1 transcript (splice variant), 288 orthologues, 7 paralogues and is associated with 16 phenotypes. Biased expression in Brain (RPKM 78.5) and Muscle (RPKM 6.3).

Summary

Enables group III metabotropic glutamate receptor activity. Involved in detection of mechanical stimulus involved in sensory perception of pain; glutamatergic synaptic transmission; and regulation of synaptic vesicle exocytosis. Located in neuron projection; neuronal cell body; and presynaptic membrane. Is integral component of plasma membrane. Is active in GABA-ergic synapse and glutamatergic synapse. Is integral component of presynaptic active zone membrane. Used to study Parkinsonism; epilepsy; and visual epilepsy. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; autistic disorder; and schizophrenia. Orthologous to human GRM8 (glutamate metabotropic receptor 8). [provided by Alliance of Genome Resources, Apr 2022]

Grm8 Products (1)

mRNA Protein Name
NM_022202.1 NP_071538.1 metabotropic glutamate receptor 8 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables group III metabotropic glutamate receptor activity IDA
IDA: Inferred from direct assay
9875342 RGD
Biological Process GO Annotation Evidence References Source
involved in chemical synaptic transmission IDA
IDA: Inferred from direct assay
15275822 RGD
involved in detection of mechanical stimulus involved in sensory perception of pain IDA
IDA: Inferred from direct assay
18533199 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
15275822 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
15275822 RGD
involved in regulation of neurotransmitter secretion IDA
IDA: Inferred from direct assay
16084932 RGD
involved in synaptic transmission, glutamatergic IDA
IDA: Inferred from direct assay
15275822 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse EXP
EXP: Inferred from Experiment
15275822 RGD
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
9295396 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
15275822 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9295396 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12443992 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
16045496 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
9295396 RGD
located in presynaptic membrane IDA
IDA: Inferred from direct assay
15275822 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Grm8 Protein Structure

PBP1_mGluR_groupIII

PBP1_mGluR_groupIII: cd06376 (39 - 503)

NCD3G

NCD3G: pfam07562 (511 - 561)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (581 - 891)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (581 - 606)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (618 - 639)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (648 - 672)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (694 - 714)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (744 - 770)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (778 - 801)

7tmC_mGluR8

7tmC_mGluR8: cd15454 (811 - 836)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 908 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 8

  • G protein-coupled receptor, family C, group 1, member H

  • glutamate receptor, metabotropic 8

  • metabotropic glutamate receptor subtype 8b

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05840 GRM8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05841 Grm8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05842 Grm8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Grm8 NCBI NCBI:2918