GRM8 - glutamate metabotropic receptor 8 Gene

Also Known as GLUR8; mGlu8; GPRC1H; MGLUR8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2918

About GRM8

Cytogenetic location: 7q31.33 Genomic coordinates (GRCh38): 7:126,438,598-127,252,941 (from NCBI)

This gene has 15 transcripts (splice variants), 288 orthologues and 7 paralogues. Biased expression in brain (RPKM 1.2), testis (RPKM 1.0) and 9 other tissues.

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GRM8 Products (26)

mRNA Protein Name
NM_001371083.1 NP_001358012.1 metabotropic glutamate receptor 8 isoform a precursor
XM_017012075.2 XP_016867564.1 metabotropic glutamate receptor 8 isoform X3
NM_001371085.1 NP_001358014.1 metabotropic glutamate receptor 8 isoform b precursor
XM_047420275.1 XP_047276231.1 metabotropic glutamate receptor 8 isoform X4
XM_047420274.1 XP_047276230.1 metabotropic glutamate receptor 8 isoform X4
XM_017012077.2 XP_016867566.1 metabotropic glutamate receptor 8 isoform X3
NM_001371086.1 NP_001358015.1 metabotropic glutamate receptor 8 isoform c precursor
NR_028041.1
XM_047420270.1 XP_047276226.1 metabotropic glutamate receptor 8 isoform X2
NM_001127323.1 NP_001120795.1 metabotropic glutamate receptor 8 isoform b precursor
XM_017012078.2 XP_016867567.1 metabotropic glutamate receptor 8 isoform X3
XM_047420277.1 XP_047276233.1 metabotropic glutamate receptor 8 isoform X5
NR_163850.1
NM_001371088.1 NP_001358017.1 metabotropic glutamate receptor 8 isoform e precursor
XR_007060010.1
NM_000845.3 NP_000836.2 metabotropic glutamate receptor 8 isoform a precursor
NM_001371087.1 NP_001358016.1 metabotropic glutamate receptor 8 isoform d
XM_017012076.2 XP_016867565.1 metabotropic glutamate receptor 8 isoform X3
XM_047420276.1 XP_047276232.1 metabotropic glutamate receptor 8 isoform X3
XM_047420269.1 XP_047276225.1 metabotropic glutamate receptor 8 isoform X1
NM_001371084.1 NP_001358013.1 metabotropic glutamate receptor 8 isoform a precursor
NR_163849.1
XM_047420272.1 XP_047276228.1 metabotropic glutamate receptor 8 isoform X3
XM_047420271.1 XP_047276227.1 metabotropic glutamate receptor 8 isoform X3
XM_017012079.2 XP_016867568.1 metabotropic glutamate receptor 8 isoform X3
XM_047420273.1 XP_047276229.1 metabotropic glutamate receptor 8 isoform X4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled receptor activity IMP
IMP: Inferred from mutant phenotype
9473604 GOA
enables glutamate receptor activity IMP
IMP: Inferred from mutant phenotype
9473604 GOA
Biological Process GO Annotation Evidence References Source
involved in adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9473604 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
11166323 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRM8 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (75 - 477)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (512 - 562)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (593 - 841)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 908 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 8

  • glutamate receptor, metabotropic 8

GRM8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83787 GRM8 Antibody (YA3484) WB, FC, ELISA Human
HY-P83787A GRM8 Antibody (YA3484)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Attention Deficit-Hyperactivity Disorder

  • Attention Deficit Hyperactivity Disorder

  • ADHD

  • Attention Deficit Disorder

  • Attention Deficit-Hyperactivity Disorder, Susceptibility To

  • Attention Deficit Disorder With Hyperactivity

  • Hyperkinetic Disorder

  • Hyperactivity Of Childhood

  • Attention-Deficit/Hyperactivity Disorder

  • Add

  • Addh

  • Attention Deficit

  • Attention Deficit Disorder Of Childhood With Hyperactivity

  • Attention Deficit Disorder With Hyperactivity Syndrome

  • Hyperkinetic Syndrome

  • Attention-Deficit Hyperactivity Disorder

  • Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

  • Disturbance Of Activity And Attention

  • Disorder Of Activity And Attention

  • Adhd - [Attention Deficit Hyperactivity Disorder]

  • Hyperkinetic Disorders

  • Disorder Of Activity And Attention With Hyperkinesia

  • Attention Deficit Syndrome With Hyperactivity
Epilepsy

  • Epilepsy Syndrome

  • Epileptic Syndrome

  • Epilepsies

  • Symptomatic Epilepsies

  • Post Traumatic Epilepsy

  • Traumatic Epilepsy

  • Traumatic Epileptic

  • Epilepsy Due To Hippocampal Sclerosis

  • Epilepsy With Ammon'S Horn Sclerosis

  • Epilepsy Due To Cortical Dysplasia

  • Epilepsy Due To Neuronal Migration Disorders
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05840 GRM8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05841 Grm8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05842 Grm8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GRM8 VGNC VGNC:106761
Felis catus GRM8 VGNC VGNC:67481
Rattus norvegicus GRM8 RGD RGD:619858
Macaca mulatta GRM8 VGNC VGNC:73292
Canis familiaris GRM8 VGNC VGNC:41515
Mus musculus GRM8 MGD MGI:1351345
Others GRM8 NCBI