2. Gene
  3. GRM8 - glutamate metabotropic receptor 8 Gene

GRM8 - glutamate metabotropic receptor 8 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as GLUR8; mGlu8; GPRC1H; MGLUR8

Gene ID: 2918 | Gene type: protein coding

About GRM8

Cytogenetic location: 7q31.33 Genomic coordinates (GRCh38): 7:126,438,598-127,252,941 (from NCBI)

This gene has 15 transcripts (splice variants), 288 orthologues and 7 paralogues. Biased expression in brain (RPKM 1.2), testis (RPKM 1.0) and 9 other tissues.

Summary

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and Metabotropic Glutamate Receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The Metabotropic Glutamate Receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate Phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GRM8 Products(26)

mRNA Protein Name
NM_001371083.1 NP_001358012.1 metabotropic glutamate receptor 8 isoform a precursor
XM_017012075.2 XP_016867564.1 metabotropic glutamate receptor 8 isoform X3
NM_001371085.1 NP_001358014.1 metabotropic glutamate receptor 8 isoform b precursor
XM_047420275.1 XP_047276231.1 metabotropic glutamate receptor 8 isoform X4
XM_047420274.1 XP_047276230.1 metabotropic glutamate receptor 8 isoform X4
XM_017012077.2 XP_016867566.1 metabotropic glutamate receptor 8 isoform X3
NM_001371086.1 NP_001358015.1 metabotropic glutamate receptor 8 isoform c precursor
NR_028041.1
XM_047420270.1 XP_047276226.1 metabotropic glutamate receptor 8 isoform X2
NM_001127323.1 NP_001120795.1 metabotropic glutamate receptor 8 isoform b precursor
XM_017012078.2 XP_016867567.1 metabotropic glutamate receptor 8 isoform X3
XM_047420277.1 XP_047276233.1 metabotropic glutamate receptor 8 isoform X5
NR_163850.1
NM_001371088.1 NP_001358017.1 metabotropic glutamate receptor 8 isoform e precursor
XR_007060010.1
NM_000845.3 NP_000836.2 metabotropic glutamate receptor 8 isoform a precursor
NM_001371087.1 NP_001358016.1 metabotropic glutamate receptor 8 isoform d
XM_017012076.2 XP_016867565.1 metabotropic glutamate receptor 8 isoform X3
XM_047420276.1 XP_047276232.1 metabotropic glutamate receptor 8 isoform X3
XM_047420269.1 XP_047276225.1 metabotropic glutamate receptor 8 isoform X1
NM_001371084.1 NP_001358013.1 metabotropic glutamate receptor 8 isoform a precursor
NR_163849.1
XM_047420272.1 XP_047276228.1 metabotropic glutamate receptor 8 isoform X3
XM_047420271.1 XP_047276227.1 metabotropic glutamate receptor 8 isoform X3
XM_017012079.2 XP_016867568.1 metabotropic glutamate receptor 8 isoform X3
XM_047420273.1 XP_047276229.1 metabotropic glutamate receptor 8 isoform X4

GRM8 Protein Structure

ANF_receptor

ANF_receptor: Receptor family ligand binding region (75 - 477)

NCD3G

NCD3G: Nine Cysteines Domain of family 3 GPCR (512 - 562)

7tm_3

7tm_3: 7 transmembrane sweet-taste receptor of 3 GCPR (593 - 841)

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  • 908 a.a.
Protein Preferred Names Protein Names

metabotropic glutamate receptor 8

glutamate receptor, metabotropic 8

Recombinant GRM8 Proteins

Cat. No. Product Name Accession Purity
HY-P79401 mGluR8 Protein, Human (CHO, His) O00222-1 (Q34-S514) ≥95%

Related Diseases

Diseases Alias
Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder

ADHD

Attention Deficit Disorder

Attention Deficit-Hyperactivity Disorder, Susceptibility To

Attention Deficit Disorder With Hyperactivity

Hyperkinetic Disorder

Hyperactivity Of Childhood

Attention-Deficit/Hyperactivity Disorder

Add

Addh

Attention Deficit

Attention Deficit Disorder Of Childhood With Hyperactivity

Attention Deficit Disorder With Hyperactivity Syndrome

Hyperkinetic Syndrome

Attention-Deficit Hyperactivity Disorder

Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type

Disturbance Of Activity And Attention

Disorder Of Activity And Attention

Adhd - [Attention Deficit Hyperactivity Disorder]

Hyperkinetic Disorders

Disorder Of Activity And Attention With Hyperkinesia

Attention Deficit Syndrome With Hyperactivity
Epilepsy

Epilepsy Syndrome

Epileptic Syndrome

Epilepsies

Symptomatic Epilepsies

Post Traumatic Epilepsy

Traumatic Epilepsy

Traumatic Epileptic

Epilepsy Due To Hippocampal Sclerosis

Epilepsy With Ammon'S Horn Sclerosis

Epilepsy Due To Cortical Dysplasia

Epilepsy Due To Neuronal Migration Disorders
Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05840 GRM8 Human Pre-designed siRNA Set A / Unkown
HY-RS05842 Grm8 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GRM8 VGNC VGNC:106761
Felis catus GRM8 VGNC VGNC:67481
Rattus norvegicus GRM8 RGD RGD:619858
Macaca mulatta GRM8 VGNC VGNC:73292
Canis familiaris GRM8 VGNC VGNC:41515
Mus musculus GRM8 MGD MGI:1351345