Actn4 - actinin alpha 4 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 60595

Summary

Enables actin filament binding activity. Involved in several processes, including bicellular tight junction assembly; positive regulation of pinocytosis; and protein localization to bicellular tight junction. Located in several cellular components, including Z disc; cytoskeleton; and pseudopodium. Is expressed in early conceptus and heart. Used to study focal segmental glomerulosclerosis 1. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Actn4 Products (4)

mRNA Protein Name
NM_001360548.1 NP_001347477.1 alpha-actinin-4 isoform 2
NM_001360549.1 NP_001347478.1 alpha-actinin-4 isoform 3
NM_001360550.1 NP_001347479.1 alpha-actinin-4 isoform 4
NM_021895.3 NP_068695.1 alpha-actinin-4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin filament binding IDA
IDA: Inferred from direct assay
15465019 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12960352 MGI
enables structural constituent of cytoskeleton IMP
IMP: Inferred from mutant phenotype
12782671 MGI
Biological Process GO Annotation Evidence References Source
involved in actin filament bundle assembly IDA
IDA: Inferred from direct assay
15841212 MGI
involved in bicellular tight junction assembly IMP
IMP: Inferred from mutant phenotype
18332111 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
16501493 MGI
involved in glomerulus development IDA
IDA: Inferred from direct assay
12782671 MGI
involved in podocyte cell migration IMP
IMP: Inferred from mutant phenotype
16837921 MGI
involved in positive regulation of pinocytosis IMP
IMP: Inferred from mutant phenotype
10954430 MGI
involved in protein localization to bicellular tight junction IMP
IMP: Inferred from mutant phenotype
18332111 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
20215401 MGI
located in cell-cell junction IDA
IDA: Inferred from direct assay
18332111 MGI
located in cortical actin cytoskeleton IDA
IDA: Inferred from direct assay
16837921 MGI
located in cortical cytoskeleton IDA
IDA: Inferred from direct assay
12960352 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12960352 MGI
located in focal adhesion IDA
IDA: Inferred from direct assay
16837921 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
33228246 MGI
located in pseudopodium IDA
IDA: Inferred from direct assay
15633123 MGI
colocalizes with stress fiber IDA
IDA: Inferred from direct assay
23890175 MGI
located in stress fiber IDA
IDA: Inferred from direct assay
15841212 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-actinin-4

  • F-actin cross-linking protein

  • non-muscle alpha-actinin 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-181126 G194-0712 Activator 99.82% Unkown
HY-RS00226 ACTN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20360 Actn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26869 Actn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Actn4 NCBI NCBI:81