RPL38 - ribosomal protein L38 Gene

Also Known as L38

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6169

About RPL38

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:74,203,678-74,210,655 (from NCBI)

This gene has 8 transcripts (splice variants) and 234 orthologues. Ubiquitous expression in ovary (RPKM 645.4), fat (RPKM 429.7) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L38E family of ribosomal proteins. It is located in the cytoplasm. Alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome, including one located in the promoter region of the type 1 angiotensin II receptor gene. [provided by RefSeq, Jul 2008]

RPL38 Products (2)

mRNA Protein Name
NM_000999.4 NP_000990.1 60S ribosomal protein L38
NM_001035258.2 NP_001030335.1 60S ribosomal protein L38

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
Biological Process GO Annotation Evidence References Source
involved in cytoplasmic translation IDA
IDA: Inferred from direct assay
25957688 GOA
Cellular Component GO Annotation Evidence References Source
part of cytosolic large ribosomal subunit IDA
IDA: Inferred from direct assay
25957688 GOA
part of cytosolic large ribosomal subunit IPI
IPI: Inferred from physical interaction
25901680 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
is active in postsynaptic density EXP
EXP: Inferred from Experiment
21170055 GOA
is active in postsynaptic density IDA
IDA: Inferred from direct assay
21170055 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPL38 Protein Structure

Ribosomal_L38e

Ribosomal_L38e: Ribosomal L38e protein family (2 - 69)

  • 0
  • 70 a.a.
Protein Preferred Names Protein Names

60S ribosomal protein L38

  • large ribosomal subunit protein eL38

RPL38 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPL38 P63173 BCCIP Homo sapiens Q9P287
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dyskeratosis Congenita, X-Linked

  • DKCX

  • X-Linked Dyskeratosis Congenita

  • Zinsser-Cole-Engman Syndrome

  • Hoyeraal-Hreidarsson Syndrome

  • Dyskeratosis Congenita X-Linked

  • HHS

  • Cerebellar Hypoplasia With Pancytopenia

  • Prenatal Growth Retardation With Progressive Pancytopenia And Cerebellar Hypoplasia

  • Dyskeratosis Congenita
Tympanosclerosis

  • Ts - [Tympanosclerosis]

  • Tympanic Membrane Sclerosis
Tympanic Membrane Disease

  • Disorder Of Tympanic Membrane
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Atrial Septal Defect 2

  • ASD2

  • Atrial Heart Septal Defect 2

  • Atrial Septal Defect-2

  • Asd Ii

  • Septal Defect, Atrial, Type 2
Shwachman-Diamond Syndrome 1

  • Shwachman-Diamond Syndrome

  • Shwachman Syndrome

  • Shwachman-Bodian-Diamond Syndrome

  • Sds

  • Pancreatic Insufficiency And Bone Marrow Dysfunction

  • Shwachman-Bodian Syndrome

  • SDS1

  • Lipomatosis Of Pancreas, Congenital

  • Congenital Lipomatosis Of Pancreas

  • Shwachman-Diamond Type Metaphyseal Dysplasia

  • Metaphyseal Chondrodysplasia, Shwachman Type

  • Shwachman-Diamond-Oski Syndrome
Dyskeratosis Congenita

  • Dyskeratosis Congenita Autosomal Dominant

  • Dc

  • Dkc

  • Zinsser-Engman-Cole Syndrome

  • Dyskeratosis Congenita, Autosomal Dominant

  • Autosomal Dominant Dyskeratosis Congenita

  • Dkca

  • Dyskeratosis Congenita Scoggins Type

  • Zinsser-Cole-Engman Syndrome

  • X-Linked Dyskeratosis Congenita

  • Hoyeraal-Hreidarsson Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12195 RPL38 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22786 Rpl38 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29300 Rpl38 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPL38 MGD MGI:1914921
Bos taurus RPL38 VGNC VGNC:107276
Rattus norvegicus RPL38 RGD RGD:1305573
Others RPL38 NCBI