TSPAN31 - tetraspanin 31 Gene

Also Known as SAS

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6302

About TSPAN31

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:57,745,039-57,750,219 (from NCBI)

This gene has 14 transcripts (splice variants), 201 orthologues and 32 paralogues. Ubiquitous expression in thyroid (RPKM 18.9), adrenal (RPKM 13.0) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. [provided by RefSeq, Jul 2008]

TSPAN31 Products (3)

mRNA Protein Name
NM_001330168.2 NP_001317097.1 tetraspanin-31 isoform 2
NM_001330169.2 NP_001317098.1 tetraspanin-31 isoform 3 precursor
NM_005981.5 NP_005972.1 tetraspanin-31 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TSPAN31 Protein Structure

Tetraspannin

Tetraspannin: Tetraspanin family (8 - 194)

  • 0
  • 100
  • 200
  • 210 a.a.
Protein Preferred Names Protein Names

tetraspanin-31

  • sarcoma-amplified sequence

TSPAN31 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TSPAN31 Q12999 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra
TSPAN31 Q12999 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra
TSPAN31 Q12999 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TSPAN31 Proteins

Cat. No. Product Name Accession Purity
HY-P76686 TSPAN31 Protein, Human (HEK293, Fc) Q12999 (C94-K173) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Breast Liposarcoma

  • Liposarcoma Of The Breast
Childhood Liposarcoma

  • Pediatric Liposarcoma
Well-Differentiated Liposarcoma

  • Atypical Lipomatous Tumor

  • Atypical Lipoma

  • Alt

  • Wdls

  • Liposarcoma, Well Differentiated

  • Pleomorphic Lipoma
Soft Tissue Chondroma

  • Extraskeletal Chondroma
Liposarcoma

  • Lipomatous Cancer
Sarcoma

  • Connective And Soft Tissue Neoplasm

  • Tumor Of Soft Tissue And Skeleton

  • Sarcomas

  • Sarcoma - Category
Pleomorphic Liposarcoma

  • Pls

  • Liposarcoma Pleomorphic

  • Liposarcoma, Pleomorphic
Diffuse Lipomatosis
Embryonal Rhabdomyosarcoma

  • Rhabdomyosarcoma, Embryonal

  • Rhabdomyosarcoma Embryonal

  • Botryoid Rhabdomyosarcoma

  • Erms

  • Spindle Cell Rhabdomyosarcomas
Retroperitoneal Sarcoma
Dedifferentiated Liposarcoma

  • Ddls

  • Liposarcoma Dedifferentiated

  • Liposarcoma, Dedifferentiated
Peripheral Osteosarcoma

  • Surface Osteosarcoma

  • Bone Surface Osteosarcoma
Cellular Myxoid Liposarcoma

  • Round Cell Liposarcoma
Anaplastic Astrocytoma

  • Grade Iii Astrocytoma

  • Astrocytoma, Anaplastic

  • Grade Iii Astrocytic Tumor
Lipomatosis, Multiple

  • Lipoma

  • Familial Multiple Lipomatosis

  • Lipomatosis, Familial Multiple

  • Benign Lipomatous Tumor

  • Lipomatous Neoplasm

  • Multiple Lipomatosis

  • Fml

  • Lipo

  • Benign Tumor Of Adipose Tissue

  • Lipomatous Tumor

  • Tumor Of Adipose Tissue

  • Neoplasms, Adipose Tissue

  • Lipomas
Familial Retinoblastoma

  • Hereditary Retinoblastoma

  • Retinoblastoma
Myxoid Liposarcoma

  • Myxoid/Round Cell Liposarcoma

  • Liposarcoma, Myxoid

  • Mrcls

  • Myxoliposarcoma

  • MXLIPO

  • Liposarcoma Myxoid

  • Liposarcoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15167 TSPAN31 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19845 Tspan31 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26343 Tspan31 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TSPAN31 MGD MGI:1914375
Bos taurus TSPAN31 VGNC VGNC:36437
Canis familiaris TSPAN31 VGNC VGNC:47920
Macaca mulatta TSPAN31 VGNC VGNC:78552
Rattus norvegicus TSPAN31 RGD RGD:1309876
Felis catus TSPAN31 VGNC VGNC:66631
Others TSPAN31 NCBI