P2ry4 - pyrimidinergic receptor P2Y4 Gene

Also Known as P2Y4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 63843

About P2ry4

Primary_assembly X: 65,683,232-65,721,748 reverse strand.mRatBN7.2:CM026994.1

This gene has 4 transcripts (splice variants), 168 orthologues, 13 paralogues and is associated with 3 phenotypes. Biased expression in Adrenal (RPKM 16.9), Lung (RPKM 14.4) and 9 other tissues.

Summary

Enables ATP binding activity. Involved in regulation of presynaptic cytosolic calcium ion concentration and regulation of synaptic vesicle exocytosis. Located in apical plasma membrane and basolateral plasma membrane. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Orthologous to human P2RY4 (pyrimidinergic receptor P2Y4). [provided by Alliance of Genome Resources, Apr 2022]

P2ry4 Products (1)

mRNA Protein Name
NM_031680.1 NP_113868.1 P2Y purinoceptor 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IDA
IDA: Inferred from direct assay
11557527 RGD
Biological Process GO Annotation Evidence References Source
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: Inferred from Experiment
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IEP
IEP: Inferred from expression pattern
16000618 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IEP
IEP: Inferred from expression pattern
16000618 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
11557527 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11557527 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
16000618 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
16000618 RGD
is active in presynaptic active zone membrane IDA
IDA: Inferred from direct assay
16000618 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry4 Protein Structure

7tmA_P2Y4

7tmA_P2Y4: cd15374 (31 - 312)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (31 - 58)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (65 - 90)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (103 - 133)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (145 - 167)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (192 - 221)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (233 - 263)

7tmA_P2Y4

7tmA_P2Y4: cd15374 (280 - 305)

  • 0
  • 100
  • 200
  • 300
  • 361 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 4

  • P2Y ATP receptor 4

  • purinergic receptor P2Y, G-protein coupled 4

  • pyrimidinergic receptor P2Y, G-protein coupled, 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09931 P2RY4 Human Pre-designed siRNA Set A / Unkown
HY-RS09932 P2ry4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09933 P2ry4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P2ry4 NCBI NCBI:5030