P2RY4 - pyrimidinergic receptor P2Y4 Gene

Also Known as NRU; P2P; UNR; P2Y4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5030

About P2RY4

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,258,166-70,260,204 (from NCBI)

This gene has 1 transcript (splice variant), 168 orthologues and 15 paralogues.

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to uridine nucleotides, partially responsive to ATP, and not responsive to ADP. [provided by RefSeq, Jul 2008]

P2RY4 Products (1)

mRNA Protein Name
NM_002565.4 NP_002556.1 P2Y purinoceptor 4

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (53 - 306)

  • 0
  • 100
  • 200
  • 300
  • 365 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 4

  • pyrimidinergic receptor P2Y, G-protein coupled, 4

  • uridine nucleotide receptor

P2RY4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
P2RY4 P51582 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Intra
P2RY4 P51582 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
P2RY4 P51582 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

P2RY4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84370 P2RY4 Antibody (YA4067) WB, IHC-P, ELISA Human
HY-P84370A P2RY4 Antibody (YA4067)(PBS only) WB, IHC-P, ELISA Human
HY-P84371 P2RY4 Antibody (YA4068) IHC-P, ICC/IF, FC, ELISA Human
HY-P84371A P2RY4 Antibody (YA4068)(PBS only) IHC-P, ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Desmoid Disease, Hereditary

  • Fif

  • DESMD

  • Hereditary Desmoid Disease

  • Familial Infiltrative Fibromatosis

  • Fibromatosis, Familial Infiltrative

  • Fibromatosis, Aggressive
Infiltrative Basal Cell Carcinoma

  • Skin Infiltrating Basal Cell Carcinoma
Cystic Fibrosis

  • Mucoviscidosis

  • CF

  • Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

  • Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

  • Cystic Fibrosis Lung Disease, Modifier Of

  • Cystic Fibrosis Of Pancreas

  • Fibrocystic Disease Of Pancreas

  • Cf - [Cystic Fibrosis]

  • Cystic Fibrosis Nos

  • Fibrocystic Disease

  • Fibrocystic Disease Of The Pancreas

  • Mucoviscidosis Of Pancreas

  • Nonproliferative Fibrocystic Disease

  • Pancreatic Cystic Fibrosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09931 P2RY4 Human Pre-designed siRNA Set A / Unkown
HY-RS09932 P2ry4 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09933 P2ry4 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta P2RY4 VGNC VGNC:75739
Bos taurus P2RY4 VGNC VGNC:32529
Rattus norvegicus P2RY4 RGD RGD:61798
Mus musculus P2RY4 MGD MGI:1926594
Felis catus P2RY4 VGNC VGNC:68675
Others P2RY4 NCBI