Glrx - glutaredoxin Gene

Also Known as Grx; Glrx1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64045

Summary

Enables glutathione disulfide oxidoreductase activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of secretion by cell; and regulation of signal transduction. Located in several cellular components, including dendrite; mitochondrial intermembrane space; and neuronal cell body. Biomarker of obesity and transient cerebral ischemia. Orthologous to human GLRX (glutaredoxin). [provided by Alliance of Genome Resources, Apr 2022]

Glrx Products (1)

mRNA Protein Name
NM_022278.1 NP_071614.1 glutaredoxin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glutathione disulfide oxidoreductase activity IDA
IDA: Inferred from direct assay
12135599 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to estradiol stimulus IDA
IDA: Inferred from direct assay
16549430 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
17324929 RGD
involved in negative regulation of hydrogen peroxide-mediated programmed cell death IMP
IMP: Inferred from mutant phenotype
19938943 RGD
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: Inferred from mutant phenotype
16893901 RGD
involved in ovulation cycle process IEP
IEP: Inferred from expression pattern
15956334 RGD
involved in positive regulation of cell adhesion molecule production IMP
IMP: Inferred from mutant phenotype
17324929 RGD
involved in positive regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
19299446 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
19299446 RGD
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
19938943 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
19938943 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
20620191 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20620191 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutaredoxin-1

  • TTase-1

  • glutaredoxin (thioltransferase)

  • glutaredoxin 1 (thioltransferase)

  • thioltransferase-1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125848 Ginsenoside F2 99.92% Unkown
HY-RS05499 GLRX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05497 GLRX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05496 GLRX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05498 GLRX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18939 Glrx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22529 Glrx5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25429 Glrx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29049 Glrx5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glrx NCBI NCBI:2745