Pi4ka - phosphatidylinositol 4-kinase alpha Gene

Also Known as Pik4ca

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64161

About Pi4ka

Primary_assembly 11: 83,609,069-83,724,080 forward strand.mRatBN7.2:CM026984.1

This gene has 1 transcript (splice variant), 210 orthologues, 9 paralogues and is associated with 18 phenotypes. Biased expression in Brain (RPKM 24.2), Kidney (RPKM 119.1) and 9 other tissues.

Summary

Enables 1-phosphatidylinositol 4-kinase activity. Predicted to be involved in several processes, including phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-mediated signaling; and viral replication complex formation and maintenance. Predicted to act upstream of or within phosphorylation. Located in Golgi-associated vesicle membrane. Orthologous to human PI4KA (phosphatidylinositol 4-kinase alpha). [provided by Alliance of Genome Resources, Apr 2022]

Pi4ka Products (1)

mRNA Protein Name
NM_022301.2 NP_071637.2 phosphatidylinositol 4-kinase alpha

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol 4-kinase activity IDA
IDA: Inferred from direct assay
8662589 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi-associated vesicle membrane IDA
IDA: Inferred from direct assay
8662589 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pi4ka Protein Structure

PI4K_N

PI4K_N: cl44709 (389 - 1525)

PI4Ka

PI4Ka: cd00871 (1558 - 1733)

PI4Kc_III_alpha

PI4Kc_III_alpha: cd05167 (1794 - 2112)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2114 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 4-kinase alpha

  • PI4-kinase alpha

  • PI4K-alpha

  • leuserpin 2

  • phosphatidylinositol 4-kinase a

  • phosphatidylinositol 4-kinase, catalytic, alpha polypeptide

  • ptdIns-4-kinase alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125118 GSK-A1 Inhibitor 99.04% Unkown
HY-100603 GSK-F1 Inhibitor 95.06% Unkown
HY-RS10466 PI4KA Human Pre-designed siRNA Set A / Unkown
HY-RS10467 Pi4ka Mouse Pre-designed siRNA Set A / Unkown
HY-RS10468 Pi4ka Rat Pre-designed siRNA Set A / Unkown
HY-100603B (R)-GSK-F1 Inhibitor / Unkown
HY-148956 PI4KA-IN-1 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pi4ka NCBI NCBI:5297