Trpv6 - transient receptor potential cation channel, subfamily V, member 6 Gene

Also Known as CAT; Cac; CaT1; Ecac2; Otrpc3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64177

Summary

Enables Calcium Channel activity and identical protein binding activity. Involved in calcium ion import across plasma membrane and response to calcium ion. Acts upstream of or within calcium ion transport and parathyroid hormone secretion. Part of Calcium Channel complex. Is expressed in alimentary system; central nervous system; metanephros; and sensory organ. Human ortholog(s) of this gene implicated in hyperparathyroidism. Orthologous to human TRPV6 (transient receptor potential cation channel subfamily V member 6). [provided by Alliance of Genome Resources, Apr 2022]

Trpv6 Products (1)

mRNA Protein Name
NM_022413.4 NP_071858.3 transient receptor potential cation channel subfamily V member 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium channel activity IDA
IDA: Inferred from direct assay
12077127 MGI
enables calcium channel activity IMP
IMP: Inferred from mutant phenotype
12574114 MGI
enables identical protein binding IPI
IPI: Inferred from physical interaction
12574114 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12574114 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
17129178 MGI
involved in calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
22878123 MGI
involved in calcium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
22878123 MGI
involved in calcium ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
12574114 MGI
acts upstream of or within calcium ion transport IDA
IDA: Inferred from direct assay
12077127 MGI
acts upstream of or within parathyroid hormone secretion IMP
IMP: Inferred from mutant phenotype
17129178 MGI
involved in response to calcium ion IDA
IDA: Inferred from direct assay
22878123 MGI
Cellular Component GO Annotation Evidence References Source
part of calcium channel complex IDA
IDA: Inferred from direct assay
12574114 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily V member 6

  • calcium transport protein 1

  • epithelial calcium channel 2

  • osmosensitive transient receptor potential channel 3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-P1651 SOR-C13 Antagonist 99.12% Phase 1
HY-P1651A SOR-C13 TFA Antagonist 99.32% Phase 1
HY-P1651B SOR-C13 acetate Antagonist 99.11% Phase 1

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157574 TRPV6-IN-1 Inhibitor 99.1% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpv6 NCBI NCBI:55503