Calr - calreticulin Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64202

Summary

Enables several functions, including hormone binding activity; metal ion binding activity; and peptide binding activity. Involved in several processes, including cellular response to lithium ion; response to estradiol; and response to testosterone. Located in several cellular components, including acrosomal vesicle; endoplasmic reticulum; and perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of vitamin B12 deficiency. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; pancreatic ductal adenocarcinoma; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Apr 2022]

Calr Products (1)

mRNA	Protein	Name
NM_022399.2	NP_071794.1	calreticulin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	8500729	RGD
enables hormone binding	IPI IPI: Inferred from physical interaction	12603316	RGD
enables iron ion binding	IDA IDA: Inferred from direct assay	8500729	RGD
enables mRNA binding	IDA IDA: Inferred from direct assay	14726956	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	10833321	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	22665516	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cardiac muscle cell differentiation	IEP IEP: Inferred from expression pattern	9011638	RGD
involved in cellular response to electrical stimulus	IEP IEP: Inferred from expression pattern	28428881	RGD
involved in cellular response to lithium ion	IEP IEP: Inferred from expression pattern	16236328	RGD
involved in cellular response to virus	IEP IEP: Inferred from expression pattern	31399043	RGD
involved in response to biphenyl	IEP IEP: Inferred from expression pattern	11452518	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16339744	RGD
involved in response to glycoside	IEP IEP: Inferred from expression pattern	28428881	RGD
involved in response to peptide	IEP IEP: Inferred from expression pattern	10833321	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	9751517	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	11032977	RGD
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	8453984	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in acrosomal vesicle	IDA IDA: Inferred from direct assay	8453984	RGD
located in cell surface	IDA IDA: Inferred from direct assay	11891802	RGD
located in collagen-containing extracellular matrix	IDA IDA: Inferred from direct assay	12782144	RGD
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	33239744	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18385140	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	12782144	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	33239744	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	20607274	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	8600158	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	33239744	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12401114	RGD
located in sarcoplasmic reticulum	IDA IDA: Inferred from direct assay	8600158	RGD
located in smooth endoplasmic reticulum	IDA IDA: Inferred from direct assay	22665516	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
calreticulin	CABP3 CALBP CRP55 ERp60 HACBP calcium-binding protein 3 calregulin endoplasmic reticulum resident protein 60

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-109113	Camsirubicin	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14307	Necrocide 1		99.55%	Unkown
HY-176252	CALR ligand 1	Inducer	/	Unkown
HY-RS01847	CALR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01848	CALR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17947	Calr Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20371	Calr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24418	Calr Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26881	Calr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Calr	NCBI	NCBI:811