Aldh1l1 - aldehyde dehydrogenase 1 family, member L1 Gene

Also Known as FDH; Fthfd

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64392

Summary

Enables aldehyde dehydrogenase (NADP+) activity. Involved in bile acid signaling pathway. Part of protein-containing complex. Biomarker of cholestasis. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1). [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aldehyde dehydrogenase (NADP+) activity IDA
IDA: Inferred from direct assay
17302434 RGD
enables aldehyde dehydrogenase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
1848231 RGD
enables formyltetrahydrofolate dehydrogenase activity IDA
IDA: Inferred from direct assay
1848231 RGD
enables formyltetrahydrofolate dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
10585460 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17669278 RGD
Biological Process GO Annotation Evidence References Source
involved in 10-formyltetrahydrofolate catabolic process IDA
IDA: Inferred from direct assay
1848231 RGD
involved in 10-formyltetrahydrofolate catabolic process IMP
IMP: Inferred from mutant phenotype
10585460 RGD
involved in NADPH regeneration IDA
IDA: Inferred from direct assay
1848231 RGD
involved in folic acid metabolic process IDA
IDA: Inferred from direct assay
1848231 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
1848231 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
17669278 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytosolic 10-formyltetrahydrofolate dehydrogenase

  • 10-FTHFDH

  • 10-formyltetrahydrofolate dehydrogenase

  • FBP-CI

  • aldehyde dehydrogenase family 1 member L1

  • formyltetrahydrofolate dehydrogenase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (33)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-138097 α-NETA ≥98.0% Unkown
HY-18768 NCT-501 99.59% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-122912 ALDH1A inhibitor 673A 99.15% Unkown
HY-148466 IGUANA-1 Inhibitor 98.93% Unkown
HY-110294 CM037 Inhibitor 99.55% Unkown
HY-135841 CM010 Inhibitor 99.70% Unkown
HY-112278 NCT-506 Inhibitor 99.93% Unkown
HY-146683 KS106 99.87% Unkown
HY-146682 KS100 99.61% Unkown
HY-126003 ALDH1A1-IN-2 Inhibitor 99.31% Unkown
HY-112277 NCT-505 Inhibitor 99.37% Unkown
HY-155816 PROTAC NSD3 degrader-1 99.40% Unkown
HY-148243 IGUANA-1 free base Inhibitor 99.69% Unkown
HY-157567 FSI-TN42 Inhibitor 98.07% Unkown
HY-134917 Aldi-2 Inhibitor / Unkown
HY-146240 ALDH1A1-IN-3 Inhibitor / Unkown
HY-157872 ALDH1A1-IN-4 Inhibitor / Unkown
HY-158026 ALDH1A1-IN-5 Inhibitor / Unkown
HY-159111 KS124 / Unkown
HY-187170 BM-51 Inhibitor / Unkown
HY-18768A NCT-501 hydrochloride Inhibitor / Unkown
HY-D3185 AlDeSense AM / Unkown
HY-RS00560 ALDH1A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00561 Aldh1a1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS00562 ALDH1A1 Rat Pre-designed siRNA Set A / Unkown
HY-RS00565 ALDH1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00566 ALDH1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180872 ALDH1A1 modulator-1 / Unkown
HY-RS17566 Aldh1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21224 Aldh1l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24026 Aldh1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27740 Aldh1l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh1l1 NCBI NCBI:10840