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Art. -Nr.: HY-148243

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IGUANA-1 free base

Name: IGUANA-1 free base
Brand: MedChemExpress
SKU: HY-148243
Price: 260.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: STL5-T-0057)

1 Cited Publications

Kundenbewertung

Based on 1 publication(s) in Google Scholar

IGUANA-1 free base (STL5-T-0057) is an selective ALDH1 B1 inhibitor with an IC₅₀ value of 30 nM. IGUANA-1 free base inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC₅₀ values of 2.46 and 0.39 μM, respectively. IGUANA-1 free base can be used for the research of cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit : 99.69%
CAS. Nr.: 2756014-24-9
Formel: C₂₆H₂₄ClN₃O₂
Molecular Weight:445.94

Speicherung:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month

IGUANA-1 free base Chemical Structure

CAS. Nr.: 2756014-24-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

IC50: 30 nM (ALDH1 B1), 2.46 μM (SW480, adherent), 0.39 μM (SW480, spheroid)^[1]

Alle Aldehyde Dehydrogenase (ALDH) Isoform-spezifische Produkte anzeigen :

In Vitro

IGUANA-1 free base (compound 68) (0-10 μM) inhibits ALDH1 B1 with an IC₅₀ value of 30 nM^[1].
IGUANA-1 free base (0.01-10 μM; 4-5 d) inhibits cell growth of HEK293T cells^[1].
IGUANA-1 free base (0.01-10 μM) inhibits cell viability of SW480 cells in adherent and spheroid conditions with IC₅₀ values of 2.46 and 0.39 μM, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

HEK293T cell line
Concentration:

0.01-10 μM
Incubation Time:

4-5 d
Result:

Showed cell cytotoxicity to HEK293T cells with a GI₅₀ value of 1.7 μM.

Related Protocols :

Chemical Information

CAS. Nr. 2756014-24-9
Appearance Solid
Molecular Weight 445.94
Formel C₂₆H₂₄ClN₃O₂
Color White to off-white
SMILES

ClC1=CC(OC)=C(C2=CN(C3=NCCCN32)C4=CC=C(C5=C(OC)C=CC=C5)C=C4)C=C1
Synonyms

STL5-T-0057
Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (1)

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Journal Impact Factor

Apoptosis

Metabolism-related ALDH1B1 acts as potential predictor and therapeutic target for primary gastrointestinal diffuse large B-cell lymphoma. [Abstract]

2025 Apr 11. PMID: 40216643

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Chen Jame Kenneth, et al. Preparation of substituted imidazolium or cyclic guanidine compounds as isoform-specific aldehyde dehydrogenase inhibitors for the treatment of cancer. WO2021257696 A1. 2021.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

IGUANA-1 free base

1 Cited Publications

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Reinheit & Dokumentation
Verweise

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IGUANA-1 free base

Publications Citing Use of MedChemExpress (MCE) IGUANA-1 free base

Alle Aldehyde Dehydrogenase (ALDH) Isoform-spezifische Produkte anzeigen