Slc5a2 - solute carrier family 5 member 2 Gene

Also Known as Sglt2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64522

About Slc5a2

Primary_assembly 1: 182,847,106-182,853,306 forward strand.mRatBN7.2:CM026974.1

This gene has 2 transcripts (splice variants), 200 orthologues, 13 paralogues and is associated with 4 phenotypes. Biased expression in Kidney (RPKM 171.3) and Lung (RPKM 4.8).

Summary

Enables glucose:sodium symporter activity. Involved in glucose transmembrane transport; negative regulation of urine volume; and renal potassium excretion. Located in brush border membrane. Is integral component of membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in renal glycosuria. Orthologous to human SLC5A2 (solute carrier family 5 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc5a2 Products (1)

mRNA Protein Name
NM_022590.2 NP_072112.2 sodium/glucose cotransporter 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables D-glucose:sodium symporter activity IDA
IDA: Inferred from direct assay
7493971 RGD
Biological Process GO Annotation Evidence References Source
involved in D-glucose transmembrane transport IDA
IDA: Inferred from direct assay
7493971 RGD
involved in negative regulation of urine volume IMP
IMP: Inferred from mutant phenotype
29790389 RGD
involved in renal potassium excretion IMP
IMP: Inferred from mutant phenotype
29790389 RGD
Cellular Component GO Annotation Evidence References Source
located in brush border membrane IDA
IDA: Inferred from direct assay
14506074 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc5a2 Protein Structure

SLC5-6-like_sbd

SLC5-6-like_sbd: cl00456 (21 - 669)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
Protein Preferred Names Protein Names

sodium/glucose cotransporter 2

  • Na(+)/glucose cotransporter 2

  • low affinity Na-dependent glucose transporter (SGLT2)

  • low affinity sodium-glucose cotransporter

  • solute carrier family 5 (sodium/glucose cotransporter), member 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13286 SLC5A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13287 Slc5a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13288 Slc5a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc5a2 NCBI NCBI:6524