Adnp - activity-dependent neuroprotector homeobox Gene

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64622

Summary

This gene encodes a member of a protein family characterized by nine zinc finger motifs followed by a homeobox domain. In vitro studies demonstrate that the encoded protein interacts with the brahma-related gene1-associated or hBRM factors (BAF) gene expression regulating complex, components of the protein translation machinery, and microtubule-associated proteins. This gene has been implicated in neuroprotection through various processes that include chromatin remodeling, splicing, cytoskeletal reorganization, and Autophagy. Homozygous mutant knockout mice display embryonic lethality with defects in neural tube closure. [provided by RefSeq, Nov 2016]

Adnp Products (1)

mRNA	Protein	Name
NM_001347532.2	NP_001334461.1	activity-dependent neuroprotector homeobox protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-tubulin binding	IPI IPI: Inferred from physical interaction	16893427	RGD
enables copper ion binding	IDA IDA: Inferred from direct assay	14706557	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	14706557	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in activation of protein kinase activity	IDA IDA: Inferred from direct assay	19047645	RGD
involved in cGMP-mediated signaling	IDA IDA: Inferred from direct assay	11438390	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	16023261	RGD
involved in intracellular nitric oxide homeostasis	IDA IDA: Inferred from direct assay	16938277	RGD
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	15314252	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	16938277	RGD
involved in negative regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	15963648	RGD
involved in positive regulation of axon extension	IDA IDA: Inferred from direct assay	19047645	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	15800376	RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	19047645	RGD
involved in positive regulation of synapse assembly	IDA IDA: Inferred from direct assay	15800376	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	19130308	RGD
involved in short-term memory	IDA IDA: Inferred from direct assay	12212775	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	18072088	RGD
located in dendrite	IDA IDA: Inferred from direct assay	19130308	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16845437	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19130308	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
activity-dependent neuroprotector homeobox protein	NAP peptide activity-dependent neuroprotective protein

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105066	Davunetide		98.57%	Phase 3

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00389	ADNP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18122	Adnp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24596	Adnp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adnp	NCBI	NCBI:23394