2. Gene
  3. METTL4 - methyltransferase 4, N6-adenosine Gene

METTL4 - methyltransferase 4, N6-adenosine Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as HsT661

Gene ID: 64863 | Gene type: protein coding

About METTL4

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:2,537,530-2,571,505 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in lymph node (RPKM 4.0), thyroid (RPKM 3.9) and 25 other tissues.

Summary

Enables RNA methyltransferase activity and site-specific DNA-methyltransferase (adenine-specific) activity. Involved in nucleic acid metabolic process; regulation of RNA metabolic process; and regulation of mitochondrial DNA replication. Located in cytosol; mitochondrial matrix; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL4 Products(2)

mRNA Protein Name
NM_001308401.2 NP_001295330.1 N(6)-adenine-specific methyltransferase METTL4 isoform 2
NM_022840.5 NP_073751.3 N(6)-adenine-specific methyltransferase METTL4 isoform 1

METTL4 Protein Structure

MT-A70

MT-A70: MT-A70 (281 - 455)

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  • 100
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  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

N(6)-adenine-specific methyltransferase METTL4

N(6)-adenine-specific DNA methyltransferase METTL4

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08365 METTL4 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus METTL4 VGNC VGNC:63466
Bos taurus METTL4 VGNC VGNC:31413
Mus musculus METTL4 MGD MGI:1924031
Macaca mulatta METTL4 VGNC VGNC:81474
Rattus norvegicus METTL4 RGD RGD:1306451
Canis familiaris METTL4 VGNC VGNC:43178