METTL4 - methyltransferase 4, N6-adenosine Gene

Also Known as HsT661

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64863

About METTL4

Cytogenetic location: 18p11.32 Genomic coordinates (GRCh38): 18:2,537,530-2,571,505 (from NCBI)

This gene has 7 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in lymph node (RPKM 4.0), thyroid (RPKM 3.9) and 25 other tissues.

Summary

Enables RNA methyltransferase activity and site-specific DNA-methyltransferase (adenine-specific) activity. Involved in nucleic acid metabolic process; regulation of RNA metabolic process; and regulation of mitochondrial DNA replication. Located in cytosol; mitochondrial matrix; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

METTL4 Products (2)

mRNA Protein Name
NM_001308401.2 NP_001295330.1 N(6)-adenine-specific methyltransferase METTL4 isoform 2
NM_022840.5 NP_073751.3 N(6)-adenine-specific methyltransferase METTL4 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables RNA methyltransferase activity IDA
IDA: Inferred from direct assay
31913360 GOA
enables site-specific DNA-methyltransferase (adenine-specific) activity IDA
IDA: Inferred from direct assay
32183942 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of RNA splicing IMP
IMP: Inferred from mutant phenotype
31913360 GOA
involved in regulation of mitochondrial DNA replication IMP
IMP: Inferred from mutant phenotype
32183942 GOA
involved in regulation of mitochondrial transcription IMP
IMP: Inferred from mutant phenotype
32183942 GOA
involved in snRNA (adenine-N6)-methylation IDA
IDA: Inferred from direct assay
31913360 GOA
Cellular Component GO Annotation Evidence References Source
part of RNA N6-methyladenosine methyltransferase complex IMP
IMP: Inferred from mutant phenotype
36354136 GOA
located in cytosol IDA
IDA: Inferred from direct assay
32183942 GOA
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
32183942 GOA
located in nucleus IDA
IDA: Inferred from direct assay
31913360 GOA
part of oxidoreductase complex IMP
IMP: Inferred from mutant phenotype
36354136 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL4 Protein Structure

MT-A70

MT-A70: MT-A70 (281 - 455)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 472 a.a.
Protein Preferred Names Protein Names

N(6)-adenine-specific methyltransferase METTL4

  • N(6)-adenine-specific DNA methyltransferase METTL4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08365 METTL4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21883 Mettl4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28400 Mettl4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus METTL4 VGNC VGNC:63466
Bos taurus METTL4 VGNC VGNC:31413
Mus musculus METTL4 MGD MGI:1924031
Macaca mulatta METTL4 VGNC VGNC:81474
Rattus norvegicus METTL4 RGD RGD:1306451
Canis familiaris METTL4 VGNC VGNC:43178
Others METTL4 NCBI