SLC6A4 - solute carrier family 6 member 4 Gene

Also Known as HTT; 5HTT; OCD1; SERT; 5-HTT; SERT1; hSERT; 5-HTTLPR

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6532

About SLC6A4

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:30,194,319-30,235,697 (from NCBI)

This gene has 6 transcripts (splice variants), 204 orthologues, 19 paralogues and is associated with 2 phenotypes. Biased expression in lung (RPKM 18.0), small intestine (RPKM 13.9) and 3 other tissues.

Summary

This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]

SLC6A4 Products (1)

mRNA	Protein	Name
NM_001045.6	NP_001036.1	sodium-dependent serotonin transporter

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables antiporter activity	IDA IDA: Inferred from direct assay	27756841	GOA
enables integrin binding	IDA IDA: Inferred from direct assay	18317590	GOA
enables monoamine transmembrane transporter activity	IDA IDA: Inferred from direct assay	16024787	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11343649	GOA
enables serotonin binding	IDA IDA: Inferred from direct assay	34851672	GOA
enables serotonin:sodium:chloride symporter activity	IDA IDA: Inferred from direct assay	8987735	GOA
enables serotonin:sodium:chloride symporter activity	IMP IMP: Inferred from mutant phenotype	12869649	GOA
enables sodium ion binding	IDA IDA: Inferred from direct assay	34851672	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within monoamine transport	IDA IDA: Inferred from direct assay	16024787	GOA
involved in regulation of thalamus size	IMP IMP: Inferred from mutant phenotype	18378990	GOA
involved in response to toxic substance	IDA IDA: Inferred from direct assay	17575980	GOA
involved in serotonin uptake	IDA IDA: Inferred from direct assay	8987735	GOA
involved in serotonin uptake	IMP IMP: Inferred from mutant phenotype	7681602	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endomembrane system	IDA IDA: Inferred from direct assay	17506858	GOA
located in membrane raft	IDA IDA: Inferred from direct assay	16870614	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12869649	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC6A4 Protein Structure

5HT_transport_N

SNF

0
100
200
300
400
500
600
630 a.a.

Protein Preferred Names	Protein Names
sodium-dependent serotonin transporter	5-hydroxytryptamine (serotonin) transporter 5HT transporter Na+/Cl- dependent serotonin transporter serotonin transporter 1 solute carrier family 6 (neurotransmitter transporter), member 4 solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

SLC6A4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81893	Serotonin Transporter Antibody (YA1638)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Amusia	Receptive Amusia
Somatization Disorder	Somatoform Disorders Briquet'S Disorder Polysomatising Disorder Somatisation Disorder Somatoform Disorder
Coronary Thrombosis	Coronary Artery Thrombosis
Exhibitionism
Gilles De La Tourette Syndrome	Tourette Syndrome Tourette Disorder GTS Ts Gilles De La Tourette'S Syndrome Motor-Verbal Tic Disorder Guinon'S Disease Psychogenic Tics Tourette'S Syndrome Chronic Motor And Vocal Tic Disorder Td Tourette'S Disease Combined Vocal And Multiple Motor Tic Disorder [De La Tourette] Combined Vocal And Multiple Motor Tic Disorder Tic De La Tourette
Plantar Fascial Fibromatosis	Dupuytren'S Contracture Of Foot Ledderhose'S Disease Fibromatosis, Plantar Ledderhose Disease
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Paine Syndrome	Pain Disorder Pain Microcephaly With Spastic Diplegia Pain Syndrome
Pedophilia	Paedophilia
Psychotic Disorder	Psychotic Disorders Mental Or Behavioural Disorder Psychotic Mental Disorders
Acute Stress Disorder	Traumatic Stress Disorder Stress Disorders, Traumatic, Acute Stress Disorders, Traumatic
Cannabis Abuse	Marijuana Abuse
Intermittent Explosive Disorder	Explosive Personality Disorder
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Substance Abuse	Substance-Related Disorders Substance Abuse Problem
Bruxism	Sleep Bruxism Sleep-Related Bruxism Bruxism - Teeth Grinding Grinding Teeth Sleep Related Bruxism Teeth Grinding Sleep Related Teeth Grinding
Tic Disorder	Tics Behavioral Tic
Brunner Syndrome	Monoamine Oxidase A Deficiency Antisocial Behavior BRNRS Deficiency Of Monoamine Oxidase A X-Linked Monoamine Oxidase Deficiency Susceptibility To Antisocial Behavior Antisocial Behavior, Susceptibility To Anti-Social Behavior
Trigeminal Neuralgia	Tic Douloureux Trifacial Neuralgia Trifocal Neuralgia Neuralgia Of The Fifth Cranial Nerve Neuralgia Of 5th Cranial Nerve Infraorbital Neuralgia
Diarrhea	Diarrhoea Diarrhea Of Presumed Infectious Origin
Hypertryptophanemia	HYPTRP Hypertryptophanemia, Familial Familial Hypertryptophanemia
Adjustment Disorder	Adjustment Reaction Adjustment Disorders Adjustment Disease Brief Situational Non-Psychotic Disorder Adaptation Reaction Nos Emotional Crisis Situational Disorder Situational Disturbance Situational Maladjustment Situational Reaction Situational Reaction With Maladjustment Transient Situational Disturbance
Drug Dependence
Endogenous Depression	Clinical Depression Unipolar Depression Depressive Disorder
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Inhibited Male Orgasm	Male Orgasmic Disorder Psychosexual Dysfunction With Male Orgasmic Disorder
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Cyclothymic Disorder	Cyclothymia Cycloid Personality Cyclothymic Personality Affective Personality Disorder Cyclothymic Personality Disorder Cycloid Personality Disorder
Trichotillomania	TTM Hair-Pulling Syndrome Compulsive Hair Plucking Hair Pulling Disorder
Eating Disorder	Eating Disorders Feeding And Eating Disorders
Atypical Depressive Disorder	Atypical Depression
Paraphilia Disorder	Paraphilia Paraphilias
Alcohol Use Disorder	Alcohol Abuse Alcoholism Ethanol Abuse Alcohol Addiction Alcohol Dependence Alcoholic Intoxication, Chronic Alcohol-Related Disorders
Glossitis	Inflammation Of Tongue Tongue Inflammation Glazed Tongue
Conduct Disorder
Kleptomania	Pathological Stealing
Psychosexual Disorder	Psychosexual Disorders
Borderline Personality Disorder
Separation Anxiety Disorder	Separation Anxiety Disorder Of Childhood
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Placental Choriocarcinoma	Choriocarcinoma Of The Placenta
Constipation
Paranoid Schizophrenia	Chronic Paranoid Schizophrenia Paranoid Type Schizophrenia Paranoid Type Schizophrenia Subchronic State Paraphrenia - Late Paraphrenic Schizophrenia Schizophrenia, Paranoid
Asperger Syndrome	Asperger Disorder
Impulse Control Disorder	Disruptive, Impulse Control, And Conduct Disorders
Patulous Eustachian Tube	Pet
Cocaine Abuse	Cocaine-Related Disorders
Chronic Fatigue Syndrome	Myalgic Encephalomyelitis Postviral Fatigue Syndrome Cfs Myalgic Encephalitis Encephalomyelitis, Myalgic Chronic Fatigue Fatigue Syndrome, Chronic Benign Myalgic Encephalomyelitis Akureyri Akureyri Disease Cfs - [Chronic Fatigue Syndrome] Epidemic Neuromyasthenia Myalgic Encephalomyelitis Syndrome Me - [Myalgic Encephalomyelitis] Pvfs - [Postviral Fatigue Syndrome] Neuromyasthenia Iceland Disease Icelandic Disease
Central Nervous System Disease	CNS Cns Diseases Central Nervous System Diseases Cns Disorder
Sleep Apnea	Sleep Apnea Syndromes
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcohol Dependence, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Cascade Stomach	Hourglass Stricture Or Stenosis Of Stomach Hourglass Contraction Of Stomach Hourglass Stenosis Of Stomach Hourglass Stricture Of Stomach
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Obsessive-Compulsive Personality Disorder	Anankastic Personality Disorder Obsessive-Compulsive Personality Compulsive Personality Disorder Ocpd Obsessional Personality Disorder
Hypochondriasis	Hypochondriacal Disorder Hypochondria Hypochondriacal Neurosis Illness Anxiety Disorder Health Anxiety Disorder Hypochondriacal Reaction
Dissociative Disorder	Dissociative Disorders Dissociative Disease Dissociative Reaction
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome
Melancholia
Heroin Dependence
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Serotonin Syndrome	Serotonergic Syndrome Serotonin Storm Serotonin Toxicity Serotonin Toxidrome Malignant Carcinoid Syndrome
Restless Legs Syndrome	Wed Willis-Ekbom Disease Restless Leg Syndrome Ekbom Syndrome Wittmaack-Ekbom Syndrome Willis Ekbom Disease Ekbom'S Syndrome Rls Restless Legs Restless Legs Syndrome, Susceptibility To
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Fibromyalgia	Diffuse Myofascial Pain Syndrome Fibromyalgia Syndrome Fibromyalgia-Fibromyositis Syndrome Fibromyositis Fibrositis Fms Myofascial Pain Syndrome Myofascial Pain Syndromes
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Microphthalmia, Syndromic 13	X-Linked Colobomatous Microphthalmia-Microcephaly-Intellectual Disability-Short Stature Syndrome MCOPS13 Maine Microphthalmos Colobomatous Microphthalmia With Microcephaly, Short Stature, And Psychomotor Retardation Syndromic Microphthalmia 13 X-Linked Colobomatous Microphthalmia-Microcephaly-Short Stature-Psychomotor Retardation Syndrome Microphthalmia, Syndromic, 13 Microphthalmia, Syndromic, Type 13
Bulimia Nervosa	Bulimia Bulimia Nervosa, Susceptibility To Binge Eating Disorder BULN Bn Hyperorexia Nervosa Bulimia Nervosa 2 BULN2 Susceptibility To Bulimia Nervosa Bulimia Nervosa, Susceptibility To, Type 2 Bn - [Bulimia Nervosa] Bulimia Nos Bulimic Bingeing Binge Overeating Bouts Of Overeating Episodes Of Overeating
Pervasive Developmental Disorder	Pervasive Development Disorder Pervasive Developmental Disorders Pervasive Child Development Disorders Autistic Behavior Autism Spectrum Disorders
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Irritable Bowel Syndrome	Irritable Colon Psychogenic Ibs Ibs - [Irritable Bowel Syndrome] Spastic Bowel Syndrome
Kluver-Bucy Syndrome	Bilateral Temporal Lobe Disorder Klüver-Bucy Syndrome Klver-Bucy Syndrome Kluver Bucy Syndrome Memory Loss, Extreme Sexual Behavior, Placidity, And Visual Distractibility Post-Encephalitic Kluver Bucy Syndrome Post-Traumatic Kluver Bucy Syndrome
Cocaine Dependence
Headache	Headache Disorder
Leukodystrophy	Leukodystrophies
Mental Depression	Depression Depressive Disorder
Animal Phobia	Zoophobia Fear Of Animals
Substance Dependence
Pathological Gambling	Compulsive Gambling Gambling Gambling, Pathological Addiction Betting Addiction Gambling Betting Pathological Gambling Dependence
Social Phobia	Phobia, Social Phobia Social Phobic Anxiety Disorder
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Burning Mouth Syndrome	Orodynia Stomatodynia Stomatopyrosis Bms Burning Mouth Disorder Oral Dysesthesia Sore Mouth Syndrome Bms - [Burning Mouth Syndrome]
Fragile X Syndrome	FXS Martin-Bell Syndrome Fraxa Syndrome Marker X Syndrome X-Linked Mental Retardation And Macroorchidism Fragile X Mental Retardation Syndrome Fra Syndrome Mental Retardation, X-Linked, Associated With Marxq28 Frax Syndrome Symptomatic Form Of Fragile X Syndrome In Female Carriers Fragile-X Syndrome Fraxe Syndrome
Agoraphobia	Fear Of Open Spaces Phobia Of Going Out
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease
Dysthymic Disorder	Dysthymia Chronic Depressive Disorder Chronic Depression Depressive Personality Depressive Personality Disorder Persistent Depressive Disorder Persistent Depression
Specific Developmental Disorder
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Fallopian Tube Clear Cell Adenocarcinoma	Clear Cell Carcinoma Of The Fallopian Tube
Mood Disorder	Mood Disorders Episodic Mood Disorder
Disease Of Mental Health	Mental Health Mental Disorders
Alcoholic Psychosis	Psychoses, Alcoholic Alcoholic Psychoses
Outlet Dysfunction Constipation
Sexual Health Disorder	Sexual Health
Choriocarcinoma	Chorioepithelioma
Schizoaffective Disorder	Schizo-Affective Psychosis Schizo-Affective Type Schizophrenia Schizoaffective Psychosis Schizoaffective Schizophrenia Schizophrenia, Schizo-Affective Type Schizophreniform Psychosis, Affective Type
Alcohol-Induced Mental Disorder	Psychoses, Alcoholic
Somatoform Disorder	Physiological Malfunction Arising From Mental Factor Psychosomatic Disorder Psychophysiologic Disorders
Bipolar I Disorder	Manic Depression Nos Manic-Depressive Illness Bipolar Disorder Nos
Antisocial Personality Disorder	Dissocial Personality Disorder Asocial Personality Psychopath.Personality Psychopathic Personality Psychopathic Personality Disorder Sociopathic Personality
Generalized Anxiety Disorder	Anxiety Generalized
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Postpartum Depression	Maternity Blues Postnatal Depression Depression, Postpartum Post-Partum Depression Depression Postpartum
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Post-Traumatic Stress Disorder	PTSD Traumatic Neurosis Post Traumatic Stress Disorder Stress Disorders, Post-Traumatic Posttraumatic Stress Disorder Ptsd - [Post Traumatic Stress Disorder] Trauma-Related Disorders
Avoidant Personality Disorder	Anxious Personality Disorder Personality Disorders
Chronic Pulmonary Heart Disease
Sleep Disorder	Sleep Disorders Non-Organic Sleep Disorder
Pyromania	Firesetting Behavior Pathological Firesetting Pathological Fire-Setting
Body Dysmorphic Disorder	Dysmorphophobia Body Dysmorphia Dysmorphic Syndrome Body Dysmorphic Disorders
Amphetamine Abuse
Neurotic Disorder	Neurosis Reactive Depression Adjustment Disorders Neurotic Disorders Depressive Neurosis Neurotic Depression Neurotic Depression Reactive Type Neurotic Depressive State Psychoneurosis Depressive Disorder Depression, Neurotic
Gestational Choriocarcinoma	Gestational Chorionepithelioma Molar Pregnancy With Choriocarcinoma
Premature Ejaculation
Gastroparesis	Gastroparesis Syndrome Delayed Gastric Emptying Gastric Atonia Gastroparalysis
Phobia, Specific	Specific Phobia Simple Phobia Phobia, Simple Isolated Phobia
Sudden Infant Death Syndrome	SIDS Sudden Infant Death Syndrome, Susceptibility To Cot Death Crib Death Sudden Death Of Nonspecific Cause In Infancy Sudden Infant Death Death, Sudden, Syndrome, Infant
Myocardial Infarction	Heart Attack Myocardial Infarction, Susceptibility To Myocardial Infarction 1 Myocardial Infarction, Protection Against Myocardial Infarction, Decreased Susceptibility To Myocardial Infarction, Decreased Myocardial Infarct MCI1 Premature Myocardial Infarction Myocardial Infarction, Susceptibility To, Type 1
Retrograde Amnesia	Amnesia, Retrograde
Phobic Disorder	Phobic Disorders Phobic Anxiety Disorder
Opiate Dependence	Opioid Dependence Opioid Addiction Opiate Addiction Opioid Type Dependence Opioid-Related Disorders Opium Dependence Narcotic Dependence Intravenous Narcotism Narcotism Nos Oral Narcotism Nos
Migraine Without Aura	Common Migraine Migraine With Or Without Aura, Susceptibility To Migraine Without Aura, Susceptibility To Acute Migraine Without Aura
Alexithymia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110023R	Zimelidine dihydrochloride (Standard)	Inhibitor	/	Unkown
HY-RS13311	SLC6A4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13312	Slc6a4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13313	Slc6a4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SLC6A4	VGNC	VGNC:49971
Felis catus	SLC6A4	VGNC	VGNC:65416
Rattus norvegicus	SLC6A4	RGD	RGD:3714
Macaca mulatta	SLC6A4	VGNC	VGNC:77620
Mus musculus	SLC6A4	MGD	MGI:96285
Canis familiaris	SLC6A4	VGNC	VGNC:46465
Others	SLC6A4	NCBI