BMP8B - bone morphogenetic protein 8b Gene

Also Known as OP2; BMP8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 656

About BMP8B

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,757,182-39,788,865 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 31 paralogues. Broad expression in thyroid (RPKM 7.4), adrenal (RPKM 2.8) and 20 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic Cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

BMP8B Products (1)

mRNA Protein Name
NM_001720.5 NP_001711.2 bone morphogenetic protein 8B preproprotein

BMP8B Protein Structure

TGFb_propeptide

TGFb_propeptide: TGF-beta propeptide (34 - 251)

TGF_beta

TGF_beta: Transforming growth factor beta like domain (299 - 402)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
Protein Preferred Names Protein Names

bone morphogenetic protein 8B

  • bone morphogenetic protein 8 (osteogenic protein 2)

Recombinant BMP8B Proteins

Cat. No. Product Name Accession Purity
HY-P700032AF Animal-Free BMP-8b Protein, Human (His) P34820 (A264-H402) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Pericoronitis

  • Operculitis
Vestibulocochlear Nerve Disease

  • Vestibulocochlear Nerve Diseases

  • Acoustic Nerve Disease

  • Cochlear Nerve Diseases

  • Disturbance Of Vestibulocochlear Nerve

  • Auditory Nerve Disorder

  • Disorder Of Acoustovestibular Nerve

  • Disorder Of Eighth Nerve

  • Eighth Cranial Nerve Disorder

  • Disease Of Eighth Cranial Nerve

  • Disease Of Acoustic Nerve

  • Disease Of Auditory Nerve

  • Disorder Of 8th Cranial Nerve

  • Auditory Nerve Lesion

  • Cochlear Nerve Disorder
Vestibular Neuronitis

  • Vestibular Neuritis

  • Epidemic Neurolabyrinthitis
Photoallergic Dermatitis

  • Dermatitis, Photoallergic

  • Photoallergic Contact Dermatitis

  • Photoallergic Eczema

  • Photo-Allergic Contact Eczema
Achondroplasia

  • Achondroplastic Dwarfism

  • ACH

  • Osteosclerosis Congenita

  • Achondroplastic Physique

  • Chondrodystrophia

  • Dwarf, Achondroplastic

  • Achondroplastic Short Stature

  • Congenital Osteosclerosis
Granulomatous Endometritis
Breast Giant Fibroadenoma

  • Giant Fibroadenoma

  • Giant Fibroadenoma Of Breast
Space Motion Sickness
Vestibular Nystagmus

  • Nystagmus Associated With Disorder Of The Vestibular System
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01544 BMP8B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20865 Bmp8b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27380 Bmp8b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus BMP8B MGD MGI:107335
Others BMP8B NCBI