BMP8B - bone morphogenetic protein 8b Gene

Homo sapiens

Also known as OP2; BMP8

Gene ID: 656 | Gene type: protein coding

About BMP8B

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:39,757,182-39,788,865 (from NCBI)

This gene has 1 transcript (splice variant), 212 orthologues and 31 paralogues. Broad expression in thyroid (RPKM 7.4), adrenal (RPKM 2.8) and 20 other tissues.

Summary

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The encoded protein stimulates thermogenesis in brown adipose tissue. Expression of this gene may be downregulated in pancreatic Cancer. This gene may have arose from a gene duplication event and its gene duplicate is also present on chromosome 1. [provided by RefSeq, Jul 2016]

BMP8B Products(1)

mRNA	Protein	Name
NM_001720.5	NP_001711.2	bone morphogenetic protein 8B preproprotein

BMP8B Protein Structure

TGFb_propeptide

TGF_beta

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

bone morphogenetic protein 8B

bone morphogenetic protein 8 (osteogenic protein 2)

Recombinant BMP8B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P79377	BMP-8b Protein, Human	P34820 (A264-H402)	≥95%
HY-P700032AF	Animal-Free BMP-8b Protein, Human (His)	P34820 (A264-H402)	≥95%

Related Diseases

Diseases

Alias

Pericoronitis

Operculitis

Vestibulocochlear Nerve Disease

Vestibulocochlear Nerve Diseases	Acoustic Nerve Disease
Cochlear Nerve Diseases	Disturbance Of Vestibulocochlear Nerve
Auditory Nerve Disorder	Disorder Of Acoustovestibular Nerve
Disorder Of Eighth Nerve	Eighth Cranial Nerve Disorder
Disease Of Eighth Cranial Nerve	Disease Of Acoustic Nerve
Disease Of Auditory Nerve	Disorder Of 8th Cranial Nerve
Auditory Nerve Lesion	Cochlear Nerve Disorder

Vestibular Neuronitis

Vestibular Neuritis

Epidemic Neurolabyrinthitis

Photoallergic Dermatitis

Dermatitis, Photoallergic	Photoallergic Contact Dermatitis
Photoallergic Eczema	Photo-Allergic Contact Eczema

Achondroplasia

Achondroplastic Dwarfism	ACH
Osteosclerosis Congenita	Achondroplastic Physique
Chondrodystrophia	Dwarf, Achondroplastic
Achondroplastic Short Stature	Congenital Osteosclerosis

Granulomatous Endometritis

Breast Giant Fibroadenoma

Giant Fibroadenoma

Giant Fibroadenoma Of Breast

Space Motion Sickness

Vestibular Nystagmus

Nystagmus Associated With Disorder Of The Vestibular System

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01544	BMP8B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BMP8B	MGD	MGI:107335

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