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Trpv4 - transient receptor potential cation channel, subfamily V, member 4 Gene

Also Known as Vroac; Otrpc4

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 66026

Summary

Enables Calcium Channel activity; cytoskeletal protein binding activity; and protein kinase C binding activity. Involved in several processes, including calcium ion transport; Cytoskeleton organization; and positive regulation of microtubule depolymerization. Located in several cellular components, including focal adhesion; lamellipodium; and ruffle membrane. Colocalizes with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2C; motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to human TRPV4 (transient receptor potential cation channel subfamily V member 4). [provided by Alliance of Genome Resources, Apr 2022]

Trpv4 Products (1)

mRNA	Protein	Name
NM_023970.1	NP_076460.1	transient receptor potential cation channel subfamily V member 4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables actin binding	IDA IDA: Inferred from direct assay	20657843	RGD
enables actin filament binding	IDA IDA: Inferred from direct assay	20657843	RGD
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	20657843	RGD
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	20657843	RGD
enables calcium channel activity	IDA IDA: Inferred from direct assay	20657843	RGD
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	23136043	RGD
enables microtubule binding	IDA IDA: Inferred from direct assay	20657843	RGD
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	11081638	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20650893	RGD
enables protein kinase C binding	IDA IDA: Inferred from direct assay	20657843	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	20657843	RGD
involved in actin filament organization	IDA IDA: Inferred from direct assay	20657843	RGD
involved in calcium ion import	IDA IDA: Inferred from direct assay	20657843	RGD
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	23136043	RGD
involved in cortical microtubule organization	IDA IDA: Inferred from direct assay	20657843	RGD
involved in hypotonic response	IDA IDA: Inferred from direct assay	11081638	RGD
involved in microtubule polymerization	IDA IDA: Inferred from direct assay	20657843	RGD
involved in multicellular organismal-level water homeostasis	IMP IMP: Inferred from mutant phenotype	23136043	RGD
involved in negative regulation of neuron projection development	IDA IDA: Inferred from direct assay	20657843	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	20650893	RGD
involved in positive regulation of microtubule depolymerization	IDA IDA: Inferred from direct assay	20657843	RGD
involved in positive regulation of striated muscle contraction	IMP IMP: Inferred from mutant phenotype	32706268	RGD
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	23136043	RGD
NOT involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	23136043	RGD
NOT involved in regulation of heart rate	IMP IMP: Inferred from mutant phenotype	23136043	RGD
NOT involved in regulation of response to osmotic stress	IMP IMP: Inferred from mutant phenotype	23136043	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	22962011	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	20650893	RGD
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	20657843	RGD
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	20657843	RGD
located in filopodium	IDA IDA: Inferred from direct assay	20657843	RGD
located in focal adhesion	IDA IDA: Inferred from direct assay	20657843	RGD
located in growth cone	IDA IDA: Inferred from direct assay	20657843	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	20657843	RGD
located in ruffle membrane	IDA IDA: Inferred from direct assay	20657843	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transient receptor potential cation channel subfamily V member 4	VR-OAC osm-9-like TRP channel 4 osmosensitive transient receptor potential channel 4 transient receptor potential cation channel subf V memb 4 transient receptor potential cation channel, subfamily 5, member 4 vanilloid receptor-related osmotically a

Trpv4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Trpv4	Q9ERZ8	Aqp4	Rattus norvegicus	P47863	Anti Bait CoIP	21262839
Intra	Trpv4	Q9ERZ8	Aqp4	Rattus norvegicus	P47863-1	Anti Bait CoIP	21262839

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1177	Crotamiton	Inhibitor	98.07%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19765	GSK2798745	Inhibitor	99.80%	Phase 2

Pre-clinical Phase

Bioactive Molecules (26)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19608	GSK1016790A	Agonist	99.93%	Unkown
HY-100208	HC-067047	Antagonist	99.97%	Unkown
HY-100720	GSK2193874	Antagonist	99.91%	Unkown
HY-120691A	GSK205	Antagonist	99.47%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-19975	RN-1734	Antagonist	99.75%	Unkown
HY-19976	RN-1747	Modulator	99.27%	Unkown
HY-114400	TRPV4 agonist-1 free base	Agonist	99.69%	Unkown
HY-116291	4α-Phorbol 12,13-didecanoate	Agonist	99.30%	Unkown
HY-130573A	DMAPP triammonium	Activator	95.0%	Unkown
HY-160603	PF-05214030	Antagonist	99.81%	Unkown
HY-120962	N-Arachidonoyl Taurine	Activator	99.3%	Unkown
HY-176464	GSK2220691	Inhibitor	99.96%	Unkown
HY-160900	RN-1665	Antagonist	99.93%	Unkown
HY-162765	TRPV4-IN-5	Inhibitor	98.77%	Unkown
HY-120514	JNc-440		98.04%	Unkown
HY-112202	GSK3395879	Antagonist	/	Unkown
HY-142620	TRPV4 antagonist 3	Antagonist	/	Unkown
HY-122692	TRPV4/TRPA1-IN-1	Inhibitor	/	Unkown
HY-178509	TRPV4-KCa2.3 modulator 1	Activator	/	Unkown
HY-149823	TRPV4 antagonist 4	Antagonist	/	Unkown
HY-110270A	RN-9893 hydrochloride	Antagonist	/	Unkown
HY-182455	GSK3527497	Inhibitor	/	Unkown
HY-N2940	Bisandrographolide A	Activator	/	Unkown
HY-W721480	HC-067047 hydrochloride	Antagonist	/	Unkown
HY-181463	20-Hydroxy-N-arachidonoyl taurine	Activator	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpv4	NCBI	NCBI:59341