Smurf2 - SMAD specific E3 ubiquitin protein ligase 2 Gene

Also Known as 2810411E22Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66313

Summary

Predicted to enable SMAD binding activity; identical protein binding activity; and ubiquitin protein Ligase activity. Predicted to be involved in several processes, including negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of trophoblast cell migration; and ubiquitin-dependent protein catabolic process. Predicted to be located in nuclear speck. Predicted to be part of ubiquitin Ligase complex. Predicted to be active in cytoplasm. Is expressed in cardiovascular system; eye; genitourinary system; gut; and lung. Used to study diffuse large B-cell lymphoma. Orthologous to human SMURF2 (SMAD specific E3 ubiquitin protein Ligase 2). [provided by Alliance of Genome Resources, Apr 2022]

Smurf2 Products (2)

mRNA Protein Name
NM_001362894.1 NP_001349823.1 E3 ubiquitin-protein ligase SMURF2 isoform 2
NM_025481.3 NP_079757.2 E3 ubiquitin-protein ligase SMURF2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19379695 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase SMURF2

  • HECT-type E3 ubiquitin transferase SMURF2

  • SMAD ubiquitination regulatory factor 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-110204 Heclin Inhibitor 98.00% Unkown
HY-RS13460 SMURF2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20599 Smurf2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27107 Smurf2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smurf2 NCBI NCBI:64750