Spc25 - SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae) Gene

Also Known as Spbc25; 2600017H08Rik; 2610205L13Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66442

Summary

This gene encodes a component of the kinetochore-associated NDC80 protein complex, which is required for the mitotic spindle checkpoint and for microtubule-kinetochore attachment. During meiosis in mouse, the protein localizes to the germinal vesicle and then is associated with the chromosomes following germinal vesicle breakdown. Knockdown of this gene in oocytes results in precocious polar body extrusion, chromosome misalignment and aberrant spindle formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Spc25 Products (4)

mRNA Protein Name
NM_001199123.2 NP_001186052.1 kinetochore protein Spc25 isoform 1
NM_001199124.2 NP_001186053.1 kinetochore protein Spc25 isoform 1
NM_001305800.1 NP_001292729.1 kinetochore protein Spc25 isoform 1
NM_025565.4 NP_079841.1 kinetochore protein Spc25 isoform 2
Protein Preferred Names Protein Names

kinetochore protein Spc25

  • spindle pole body component 25 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13648 SPC25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21766 Spc25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spc25 NCBI NCBI:57405