Lamtor1 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Gene

Also Known as p18; Pdro; 2400001E08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66508

Summary

Predicted to enable GTPase binding activity. Predicted to contribute to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including lysosome localization; positive regulation of MAPK cascade; and regulation of receptor recycling. Predicted to be located in late endosome membrane and membrane raft. Predicted to be part of Ragulator complex. Predicted to be active in lysosome. Is expressed in several structures, including adipose tissue; alimentary system; early conceptus; nervous system; and reproductive system. Orthologous to human LAMTOR1 (late endosomal/lysosomal adaptor, MAPK and mTOR Activator 1). [provided by Alliance of Genome Resources, Apr 2022]

Lamtor1 Products (1)

mRNA Protein Name
NM_025605.3 NP_079881.2 ragulator complex protein LAMTOR1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19177150 MGI
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
30020076 MGI
Biological Process GO Annotation Evidence References Source
involved in endosomal transport IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in lysosome localization IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in lysosome organization IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
30020076 MGI
involved in protein localization IMP
IMP: Inferred from mutant phenotype
19177150 MGI
involved in protein localization to membrane IDA
IDA: Inferred from direct assay
30020076 MGI
involved in regulation of receptor recycling IMP
IMP: Inferred from mutant phenotype
19177150 MGI
Cellular Component GO Annotation Evidence References Source
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
30020076 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ragulator complex protein LAMTOR1

  • RhoA activator C11orf59 homolog

  • late endosomal/lysosomal adaptor and MAPK and MTOR activator 1

  • lipid raft adaptor protein p18

  • p27Kip1-releasing factor from RhoA

  • p27RF-Rho

  • ragulator complex protein PDRO

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-176166 PD-M6 98.17% Unkown
HY-RS07513 LAMTOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20212 Lamtor1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26717 Lamtor1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lamtor1 NCBI NCBI:55004