LAMTOR1 - late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 Gene

Also Known as p18; PDRO; C11orf59; p27RF-Rho; Ragulator1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55004

About LAMTOR1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:72,097,292-72,103,297 (from NCBI)

This gene has 8 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in thyroid (RPKM 58.6), adrenal (RPKM 40.5) and 25 other tissues.

Summary

Enables GTPase binding activity. Contributes to guanyl-nucleotide exchange factor activity and molecular adaptor activity. Involved in several processes, including Cholesterol homeostasis; positive regulation of TOR signaling; and regulation of Cholesterol transport. Located in lysosome. Part of Ragulator complex. [provided by Alliance of Genome Resources, Apr 2022]

LAMTOR1 Products (1)

mRNA Protein Name
NM_017907.3 NP_060377.1 ragulator complex protein LAMTOR1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
22424946 GOA
contributes to guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
22980980 GOA
contributes to molecular adaptor activity IDA
IDA: Inferred from direct assay
22980980 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20381137 GOA
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
28935770 GOA
Biological Process GO Annotation Evidence Références Source
involved in cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
22980980 GOA
involved in cellular response to amino acid stimulus IMP
IMP: Inferred from mutant phenotype
20381137 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
28935770 GOA
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
20544018 GOA
involved in positive regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
20381137 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
28935770 GOA
involved in positive regulation of protein localization to lysosome IDA
IDA: Inferred from direct assay
28935770 GOA
involved in protein localization IMP
IMP: Inferred from mutant phenotype
20381137 GOA
involved in protein localization to membrane IDA
IDA: Inferred from direct assay
28935770 GOA
involved in regulation of cell growth IMP
IMP: Inferred from mutant phenotype
20381137 GOA
involved in regulation of cholesterol efflux IMP
IMP: Inferred from mutant phenotype
20544018 GOA
involved in regulation of cholesterol import IMP
IMP: Inferred from mutant phenotype
20544018 GOA
Cellular Component GO Annotation Evidence Références Source
part of FNIP-folliculin RagC/D GAP IDA
IDA: Inferred from direct assay
36103527 GOA
part of Ragulator complex IDA
IDA: Inferred from direct assay
20381137 GOA
part of Ragulator complex IPI
IPI: Inferred from physical interaction
28935770 GOA
is active in lysosomal membrane IDA
IDA: Inferred from direct assay
29158492 GOA
located in lysosome IDA
IDA: Inferred from direct assay
20544018 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAMTOR1 Protein Structure

LAMTOR

LAMTOR: Late endosomal/lysosomal adaptor and MAPK and MTOR activator (16 - 88)

  • 0
  • 100
  • 161 a.a.
Protein Preferred Names Protein Names

ragulator complex protein LAMTOR1

  • RhoA activator C11orf59

LAMTOR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
LAMTOR1 Q6IAA8 LAMTOR3 Homo sapiens Q9UHA4
X-Ray Diffraction
29123114
Intra
LAMTOR1 Q6IAA8 LAMTOR3 Homo sapiens Q9UHA4
Anti Bait CoIP
22980980
Intra
LAMTOR1 Q6IAA8 LAMTOR3 Homo sapiens Q9UHA4
Anti Tag CoIP
25561175
Intra
LAMTOR1 Q6IAA8 LAMTOR3 Homo sapiens Q9UHA4
Lumier
37398436
Intra
LAMTOR1 Q6IAA8 LAMTOR3 Homo sapiens Q9UHA4
Anti Tag CoIP
22980980
Intra
LAMTOR1 Q6IAA8 LAMTOR3 Homo sapiens Q9UHA4
BRET
37398436
Intra
LAMTOR1 Q6IAA8 LAMTOR3 Homo sapiens Q9UHA4
Anti Tag CoIP
33961781
Intra
LAMTOR1 Q6IAA8 LAMTOR3 Homo sapiens Q9UHA4
Light Scattering
29123114
Intra
LAMTOR1 Q6IAA8 CTAG1A Homo sapiens P78358
Y2H Prey Pooling
32296183
Intra
LAMTOR1 Q6IAA8 CTAG1A Homo sapiens P78358
Y2H Array
32296183
Intra
LAMTOR1 Q6IAA8 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
Intra
LAMTOR1 Q6IAA8 CHAT Homo sapiens P28329-3
Y2H Array
32814053
Intra
LAMTOR1 Q6IAA8 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
Intra
LAMTOR1 Q6IAA8 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
Intra
LAMTOR1 Q6IAA8 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
Intra
LAMTOR1 Q6IAA8 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
Intra
LAMTOR1 Q6IAA8 LAMTOR2 Homo sapiens Q9Y2Q5
Light Scattering
29123114
Intra
LAMTOR1 Q6IAA8 LAMTOR2 Homo sapiens Q9Y2Q5
Anti Bait CoIP
22980980
Intra
LAMTOR1 Q6IAA8 LAMTOR2 Homo sapiens Q9Y2Q5
Anti Tag CoIP
25561175
Intra
LAMTOR1 Q6IAA8 LAMTOR2 Homo sapiens Q9Y2Q5
Anti Tag CoIP
22980980
Intra
LAMTOR1 Q6IAA8 LAMTOR2 Homo sapiens Q9Y2Q5
BRET
37398436
Intra
LAMTOR1 Q6IAA8 LAMTOR2 Homo sapiens Q9Y2Q5
Anti Tag CoIP
33961781
Intra
LAMTOR1 Q6IAA8 LAMTOR2 Homo sapiens Q9Y2Q5
X-Ray Diffraction
29123114
Intra
LAMTOR1 Q6IAA8 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
Intra
LAMTOR1 Q6IAA8 FGFR3 Homo sapiens P22607
Y2H Array
32814053
Intra
LAMTOR1 Q6IAA8 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
Intra
LAMTOR1 Q6IAA8 GSN Homo sapiens P06396
Y2H Array
32814053
Intra
LAMTOR1 Q6IAA8 GSN Homo sapiens P06396
Y2H Pooling
32814053
Intra
LAMTOR1 Q6IAA8 GSN Homo sapiens P06396
Validated Y2H
32814053
Intra
LAMTOR1 Q6IAA8 VIM Homo sapiens P08670
Validated Y2H
32814053
Intra
LAMTOR1 Q6IAA8 VIM Homo sapiens P08670
Y2H Pooling
32814053
Intra
LAMTOR1 Q6IAA8 VIM Homo sapiens P08670
Y2H Array
32814053
Intra
LAMTOR1 Q6IAA8 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
25561175
Intra
LAMTOR1 Q6IAA8 LAMTOR4 Homo sapiens Q0VGL1
X-Ray Diffraction
29123114
Intra
LAMTOR1 Q6IAA8 LAMTOR4 Homo sapiens Q0VGL1
Anti Bait CoIP
22980980
Intra
LAMTOR1 Q6IAA8 LAMTOR4 Homo sapiens Q0VGL1
Lumier
37398436
Intra
LAMTOR1 Q6IAA8 LAMTOR4 Homo sapiens Q0VGL1
Light Scattering
29123114
Intra
LAMTOR1 Q6IAA8 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
22980980
Intra
LAMTOR1 Q6IAA8 LAMTOR4 Homo sapiens Q0VGL1
Anti Tag CoIP
33961781
Intra
LAMTOR1 Q6IAA8 PECAM1 Homo sapiens P16284
Y2H Pooling
32814053
Intra
LAMTOR1 Q6IAA8 PECAM1 Homo sapiens P16284
Validated Y2H
32814053
Intra
LAMTOR1 Q6IAA8 PECAM1 Homo sapiens P16284
Y2H Array
32814053
Intra
LAMTOR1 Q6IAA8 RRAGA Homo sapiens Q7L523
Anti Tag CoIP
22980980
Intra
LAMTOR1 Q6IAA8 RRAGA Homo sapiens Q7L523
Anti Bait CoIP
25567906
Intra
LAMTOR1 Q6IAA8 RRAGA Homo sapiens Q7L523
Anti Bait CoIP
25561175
Intra
LAMTOR1 Q6IAA8 RRAGA Homo sapiens Q7L523
Anti Bait CoIP
22980980
Intra
LAMTOR1 Q6IAA8 RRAGA Homo sapiens Q7L523
Anti Tag CoIP
33961781
Intra
LAMTOR1 Q6IAA8 RRAGA Homo sapiens Q7L523
Anti Tag CoIP
25561175
Intra
LAMTOR1 Q6IAA8 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
22980980
Intra
LAMTOR1 Q6IAA8 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
33961781
Intra
LAMTOR1 Q6IAA8 RRAGC Homo sapiens Q9HB90
Anti Tag CoIP
25561175
Intra
LAMTOR1 Q6IAA8 RRAGC Homo sapiens Q9HB90
BiLC
37398436
Intra
LAMTOR1 Q6IAA8 RRAGC Homo sapiens Q9HB90
Anti Bait CoIP
22980980
Intra
LAMTOR1 Q6IAA8 RRAGC Homo sapiens Q9HB90
IF
20381137
Intra
LAMTOR1 Q6IAA8 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25561175
Intra
LAMTOR1 Q6IAA8 SLC38A9 Homo sapiens Q8NBW4
Anti Bait CoIP
25567906
Intra
LAMTOR1 Q6IAA8 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
25567906
Intra
LAMTOR1 Q6IAA8 SLC38A9 Homo sapiens Q8NBW4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LAMTOR1 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P71583 LAMTOR1 Protein, Human (His) Q6IAA8 (G2-P161) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-176166 PD-M6 98.17% Unkown
HY-RS07513 LAMTOR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20212 Lamtor1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26717 Lamtor1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LAMTOR1 RGD RGD:735078
Bos taurus LAMTOR1 VGNC VGNC:30779
Felis catus LAMTOR1 VGNC VGNC:82041
Canis familiaris LAMTOR1 VGNC VGNC:42577
Macaca mulatta LAMTOR1 VGNC VGNC:74129
Mus musculus LAMTOR1 MGD MGI:1913758
Others LAMTOR1 NCBI