Ctnnbip1 - catenin beta interacting protein 1 Gene

Also Known as Icat; Catnbip1; 1110008O09Rik; 2310001I19Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67087

Summary

Enables beta-catenin binding activity. Involved in several processes, including negative regulation of DNA binding activity; negative regulation of smooth muscle cell proliferation; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; negative regulation of Wnt signaling pathway; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytoplasm. Predicted to be part of beta-catenin destruction complex. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and respiratory system. Orthologous to human CTNNBIP1 (catenin beta interacting protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctnnbip1 Products (2)

mRNA	Protein	Name
NM_001141930.1	NP_001135402.1	beta-catenin-interacting protein 1
NM_023465.4	NP_075954.1	beta-catenin-interacting protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables beta-catenin binding	IPI IPI: Inferred from physical interaction	12408824	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10898789	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within anterior/posterior pattern specification	IMP IMP: Inferred from mutant phenotype	15148409	MGI
acts upstream of or within branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17803964	MGI
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	11751639	MGI
involved in negative regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	11751639	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IDA IDA: Inferred from direct assay	15148409	MGI
acts upstream of or within negative regulation of Wnt signaling pathway	IPI IPI: Inferred from physical interaction	10898789	MGI
involved in negative regulation of canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	10898789	MGI
involved in negative regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	11751639	MGI
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	17122440	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16678101	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10898789	MGI
involved in negative regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	11751639	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of beta-catenin-ICAT complex	IPI IPI: Inferred from physical interaction	10898789	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
beta-catenin-interacting protein 1	inhibitor of beta-catenin and Tcf-4

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03309	CTNNBIP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22063	Ctnnbip1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28581	Ctnnbip1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctnnbip1	NCBI	NCBI:56998