Peli1 - pellino 1 Gene

Also Known as D11Ertd676e; 2810468L03Rik; A930031K15Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67245

Summary

Enables ubiquitin protein Ligase activity. Involved in negative regulation of necroptotic process. Acts upstream of or within several processes, including positive regulation of macromolecule metabolic process; positive regulation of signal transduction; and regulation of lymphocyte proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; sensory organ; and skin. Orthologous to human PELI1 (pellino E3 ubiquitin protein Ligase 1). [provided by Alliance of Genome Resources, Apr 2022]

Peli1 Products (1)

mRNA Protein Name
NM_023324.2 NP_075813.2 E3 ubiquitin-protein ligase pellino homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19734906 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19734906 MGI
enables ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
21874024 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell activation IMP
IMP: Inferred from mutant phenotype
21874024 MGI
acts upstream of T cell proliferation IMP
IMP: Inferred from mutant phenotype
21874024 MGI
acts upstream of or within negative regulation of NF-kappaB transcription factor activity IMP
IMP: Inferred from mutant phenotype
21874024 MGI
acts upstream of or within negative regulation of T cell activation IMP
IMP: Inferred from mutant phenotype
21874024 MGI
acts upstream of or within negative regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
21874024 MGI
involved in negative regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
29883609 MGI
acts upstream of or within positive regulation of B cell activation IMP
IMP: Inferred from mutant phenotype
19734906 MGI
acts upstream of or within positive regulation of B cell proliferation IMP
IMP: Inferred from mutant phenotype
19734906 MGI
acts upstream of or within positive regulation of canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
19734906 MGI
acts upstream of or within positive regulation of cytokine production IMP
IMP: Inferred from mutant phenotype
19734906 MGI
acts upstream of or within positive regulation of protein ubiquitination IMP
IMP: Inferred from mutant phenotype
19734906 MGI
acts upstream of or within positive regulation of toll-like receptor 3 signaling pathway IMP
IMP: Inferred from mutant phenotype
19734906 MGI
acts upstream of or within positive regulation of toll-like receptor 4 signaling pathway IMP
IMP: Inferred from mutant phenotype
19734906 MGI
acts upstream of or within protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
21874024 MGI
acts upstream of or within protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
21874024 MGI
acts upstream of or within response to dsRNA IMP
IMP: Inferred from mutant phenotype
19734906 MGI
acts upstream of or within response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
19734906 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
21874024 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase pellino homolog 1

  • RING-type E3 ubiquitin transferase pellino homolog 1

  • protein pellino homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-157435 PELI1-IN-1 98.02% Unkown
HY-RS10320 PELI1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18832 Peli1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25324 Peli1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Peli1 NCBI NCBI:57162