SULT1A2 - sulfotransferase family 1A member 2 Gene

Also Known as STP2; HAST4; P-PST; ST1A2; TSPST2; P-PST 2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 6799

About SULT1A2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,591,943-28,597,050 (from NCBI)

This gene has 5 transcripts (splice variants), 762 orthologues and 12 paralogues. Biased expression in duodenum (RPKM 25.0), small intestine (RPKM 22.6) and 13 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

SULT1A2 Products (10)

mRNA Protein Name
NM_001054.4 NP_001045.2 sulfotransferase 1A2 isoform 1
NM_001363863.2 NP_001350792.1 sulfotransferase 1A2 isoform 2
NM_001400258.1 NP_001387187.1 sulfotransferase 1A2 isoform 1
NM_001400259.1 NP_001387188.1 sulfotransferase 1A2 isoform 1
NM_001400260.1 NP_001387189.1 sulfotransferase 1A2 isoform 3
NM_001400261.1 NP_001387190.1 sulfotransferase 1A2 isoform 4
NM_001400262.1 NP_001387191.1 sulfotransferase 1A2 isoform 4
NM_001400263.1 NP_001387192.1 sulfotransferase 1A2 isoform 4
NM_001400264.1 NP_001387193.1 sulfotransferase 1A2 isoform 1
NM_177528.4 NP_803564.2 sulfotransferase 1A2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence 参考文献 由来
enables aryl sulfotransferase activity IDA
IDA: Inferred from direct assay
20417180 GOA
enables flavonol 3-sulfotransferase activity IDA
IDA: Inferred from direct assay
20056724 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in ethanol catabolic process IDA
IDA: Inferred from direct assay
23207770 GOA
involved in phenol-containing compound metabolic process IDA
IDA: Inferred from direct assay
20417180 GOA
involved in sulfation IDA
IDA: Inferred from direct assay
20056724 GOA
involved in xenobiotic metabolic process IDA
IDA: Inferred from direct assay
20417180 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1A2 Protein Structure

Sulfotransfer_1

Sulfotransfer_1: Sulfotransferase domain (38 - 287)

  • 0
  • 100
  • 200
  • 295 a.a.
Protein Preferred Names Protein Names

sulfotransferase 1A2

  • aryl sulfotransferase 2

SULT1A2 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SULT1A2 P50226 NIF3L1 Homo sapiens Q9GZT8
Validated Y2H
25416956
Intra
SULT1A2 P50226 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
25416956
Intra
SULT1A2 P50226 NIF3L1 Homo sapiens Q9GZT8
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT1A2 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P71001 SULT1A2 Protein, Human (His) AAI13728.1 (M1-L295) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
Mandibulofacial Dysostosis With Alopecia

  • MFDA
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS14014 SULT1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14017 SULT1C2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20653 Sult1c2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27164 Sult1c2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus SULT1A2 MGD MGI:102896
Others SULT1A2 NCBI