SULT1A2 - sulfotransferase family 1A member 2 Gene

Also Known as STP2; HAST4; P-PST; ST1A2; TSPST2; P-PST 2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6799

About SULT1A2

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,591,943-28,597,050 (from NCBI)

This gene has 5 transcripts (splice variants), 762 orthologues and 12 paralogues. Biased expression in duodenum (RPKM 25.0), small intestine (RPKM 22.6) and 13 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

SULT1A2 Products (10)

mRNA	Protein	Name
NM_001054.4	NP_001045.2	sulfotransferase 1A2 isoform 1
NM_001363863.2	NP_001350792.1	sulfotransferase 1A2 isoform 2
NM_001400258.1	NP_001387187.1	sulfotransferase 1A2 isoform 1
NM_001400259.1	NP_001387188.1	sulfotransferase 1A2 isoform 1
NM_001400260.1	NP_001387189.1	sulfotransferase 1A2 isoform 3
NM_001400261.1	NP_001387190.1	sulfotransferase 1A2 isoform 4
NM_001400262.1	NP_001387191.1	sulfotransferase 1A2 isoform 4
NM_001400263.1	NP_001387192.1	sulfotransferase 1A2 isoform 4
NM_001400264.1	NP_001387193.1	sulfotransferase 1A2 isoform 1
NM_177528.4	NP_803564.2	sulfotransferase 1A2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables aryl sulfotransferase activity	IDA IDA: Inferred from direct assay	20417180	GOA
enables flavonol 3-sulfotransferase activity	IDA IDA: Inferred from direct assay	20056724	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in ethanol catabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in phenol-containing compound metabolic process	IDA IDA: Inferred from direct assay	20417180	GOA
involved in sulfation	IDA IDA: Inferred from direct assay	20056724	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	20417180	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1A2 Protein Structure

Sulfotransfer_1

0
100
200
295 a.a.

Protein Preferred Names	Protein Names
sulfotransferase 1A2	aryl sulfotransferase 2

SULT1A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SULT1A2	P50226	NIF3L1	Homo sapiens	Q9GZT8	Validated Y2H	25416956
Intra	SULT1A2	P50226	NIF3L1	Homo sapiens	Q9GZT8	Y2H Array	25416956
Intra	SULT1A2	P50226	NIF3L1	Homo sapiens	Q9GZT8	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT1A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71001	SULT1A2 Protein, Human (His)	AAI13728.1 (M1-L295)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Mandibulofacial Dysostosis With Alopecia	MFDA

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14014	SULT1A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14017	SULT1C2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20653	Sult1c2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27164	Sult1c2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SULT1A2	MGD	MGI:102896
Others	SULT1A2	NCBI