TACR2 - tachykinin receptor 2 Gene

Also Known as SKR; NK2R; NKNAR; TAC2R

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6865

About TACR2

Cytogenetic location: 10q22.1 Genomic coordinates (GRCh38): 10:69,403,903-69,416,918 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 33 paralogues. Biased expression in esophagus (RPKM 8.8), endometrium (RPKM 7.3) and 9 other tissues.

Summary

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

TACR2 Products (1)

mRNA Protein Name
NM_001057.3 NP_001048.2 substance-K receptor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12716968 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of flagellated sperm motility IMP
IMP: Inferred from mutant phenotype
17437961 GOA
Cellular Component GO Annotation Evidence References Source
located in sperm flagellum IDA
IDA: Inferred from direct assay
17437961 GOA
located in sperm head IDA
IDA: Inferred from direct assay
17437961 GOA
located in sperm midpiece IDA
IDA: Inferred from direct assay
17437961 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TACR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (50 - 307)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
Protein Preferred Names Protein Names

substance-K receptor

  • NK-2 receptor

  • NK-2R

  • neurokinin 2 receptor

  • neurokinin A receptor

  • neurokinin B receptor

  • seven transmembrane helix receptor

TACR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TACR2 P21452 P20366-PRO_0000033534 Homo sapiens P20366-PRO_0000033534
SPA
23597562
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Occupational Asthma
Capillary Malformations, Congenital

  • Familial Multiple Nevi Flammei

  • Nevi Flammei, Familial Multiple

  • CMC

  • Port-Wine Stain

  • Capillary Malformations

  • Cmal

  • Familial Multiple Port-Wine Stains

  • Capillary Malformation

  • Capillary Malformations, Congenital, 1, Somatic, Mosaic

  • Congenital Capillary Malformations

  • Port-Wine Stain Familial Multiple

  • Hereditary Capillary Malformations

  • Capillary Malformations, Hereditary

  • Capillary Malformations, Congenital, Type 1, Somatic, Mosaic

  • Strawberry Nevus Of Skin

  • Naevus Flammeus
Posterior Cerebral Artery Infarction

  • Infarction, Posterior Cerebral Artery
Baritosis

  • Deposition Of Barium In The Lungs

  • Inhalation Of Barytes
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Environmental Induced Asthma

  • Irritant Asthma
Constipation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P3848 Tyr0-Neurokinin A Agonist / Unkown
HY-RS14146 TACR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14147 Tacr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14148 Tacr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TACR2 VGNC VGNC:78084
Bos taurus TACR2 VGNC VGNC:35561
Rattus norvegicus TACR2 RGD RGD:3812
Canis familiaris TACR2 VGNC VGNC:47067
Mus musculus TACR2 MGD MGI:98477
Felis catus TACR2 VGNC VGNC:65921
Others TACR2 NCBI