Ubr4 - ubiquitin protein ligase E3 component n-recognin 4 Gene

Also Known as p600; Zubr1; Gm1032; Gm1666; RBAF600; mKIAA0462; 1810009A16Rik; A930005E13Rik; D930005K06Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 69116

Summary

Predicted to enable ubiquitin protein Ligase activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including cytoplasm; cytoskeleton; and nucleus. Predicted to be integral component of membrane. Predicted to be active in centrosome; cytosol; and nucleoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Orthologous to human UBR4 (ubiquitin protein Ligase E3 component n-recognin 4). [provided by Alliance of Genome Resources, Apr 2022]

Ubr4 Products (1)

mRNA Protein Name
NM_001160319.1 NP_001153791.1 E3 ubiquitin-protein ligase UBR4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IDA
IDA: Inferred from direct assay
30111582 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16081543 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19008229 MGI
Biological Process GO Annotation Evidence References Source
involved in endosome organization IDA
IDA: Inferred from direct assay
30111582 MGI
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
23431188 MGI
acts upstream of or within protein catabolic process IMP
IMP: Inferred from mutant phenotype
37871017 MGI
acts upstream of or within protein stabilization IMP
IMP: Inferred from mutant phenotype
37871017 MGI
involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway IDA
IDA: Inferred from direct assay
16055722 MGI
involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway IMP
IMP: Inferred from mutant phenotype
23431188 MGI
Cellular Component GO Annotation Evidence References Source
located in endosome IDA
IDA: Inferred from direct assay
30111582 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase UBR4

  • N-recognin-4

  • RING-type E3 ubiquitin transferase UBR4

  • retinoblastoma-associated factor 600

  • zinc finger UBR1-type protein 1

  • zinc finger, UBR1 type 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19394 Ubr4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15389 UBR4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25886 Ubr4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ubr4 NCBI NCBI:23352