UBR4 - ubiquitin protein ligase E3 component n-recognin 4 Gene

Also Known as p600; ZUBR1; RBAF600

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23352

About UBR4

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,074,510-19,210,266 (from NCBI)

This gene has 17 transcripts (splice variants) and 228 orthologues. Ubiquitous expression in testis (RPKM 21.2), bone marrow (RPKM 14.0) and 25 other tissues.

Summary

The protein encoded by this gene is an E3 ubiquitin-protein Ligase that interacts with the retinoblastoma-associated protein in the nucleus and with calcium-bound Calmodulin in the cytoplasm. The encoded protein appears to be a cytoskeletal component in the cytoplasm and part of the chromatin scaffold in the nucleus. In addition, this protein is a target of the human papillomavirus type 16 E7 oncoprotein. [provided by RefSeq, Aug 2010]

UBR4 Products (1)

mRNA Protein Name
NM_020765.3 NP_065816.2 E3 ubiquitin-protein ligase UBR4

UBR4 Protein Structure

zf-UBR

zf-UBR: Putative zinc finger in N-recognin (UBR box) (1661 - 1721)

E3_UbLigase_R4

E3_UbLigase_R4: E3 ubiquitin-protein ligase UBR4 (4367 - 5163)

  • 0
  • 800
  • 1600
  • 2400
  • 3200
  • 4000
  • 4800
  • 5183 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase UBR4

  • N-recognin-4

UBR4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
UBR4 Q5T4S7 E7 Human papillomavirus P06464
CoIP
16061792
Cross
UBR4 Q5T4S7 E7 Human papillomavirus P03129
CoIP
16061792
Cross
UBR4 Q5T4S7 E7 Human papillomavirus P03129
Anti Bait CoIP
16061792
Cross
UBR4 Q5T4S7 E7 Human papillomavirus P03129
Affinity Chrom
16061792
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rift Valley Fever

  • Rfv - [Rift Valley Fever]
Retinoblastoma

  • RB

  • Trilateral Retinoblastoma

  • RB1

  • Retinoblastoma, Trilateral

  • Neuroblastoma Of Retina

  • Rb - Retinoblastoma

  • Eye Cancer, Retinoblastoma

  • Retinal Cancer

  • Retinal Tumor

  • Glioma, Retinal

  • Non-Hereditary Retinoblastoma

  • Childhood Cancer Retinoblastoma

  • Malignant Neoplasm Of Retina

  • Retinal Neoplasms
Episodic Ataxia, Type 8

  • Episodic Ataxia Type 8

  • EA8

  • Episodic Ataxia With Slurred Speech
Episodic Ataxia, Type 4

  • Episodic Ataxia Type 4

  • Periodic Vestibulocerebellar Ataxia

  • Patx

  • EA4

  • Ataxia, Periodic Vestibulocerebellar
Johanson-Blizzard Syndrome

  • JBS

  • Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness

  • Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness

  • Johanson Blizzard Syndrome
Episodic Ataxia, Type 3

  • Episodic Ataxia Type 3

  • EA3

  • Ataxia, Episodic, With Vertigo And Tinnitus

  • Episodic Ataxia-Vertigo-Tinnitus-Myokymia Syndrome
Episodic Ataxia, Type 7

  • Episodic Ataxia Type 7

  • EA7
Episodic Ataxia, Type 5

  • Episodic Ataxia Type 5

  • EA5

  • Episodic Ataxia 5

  • Ea-5

  • Ataxia, Episodic, Type 5
Severe Congenital Neutropenia 4

  • Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency

  • Scn4

  • Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome

  • Dursun Syndrome

  • Severe Congenital Neutropenia Type 4
Epidermodysplasia Verruciformis 1

  • Epidermodysplasia Verruciformis

  • Epidermodysplasia Verruciformis, Susceptibility To, 1

  • Lutz-Lewandowsky Epidermodysplasia Verruciformis

  • EV1

  • Lewandowsky-Lutz Syndrome

  • Ev
Episodic Ataxia

  • Isaacs Syndrome

  • Neuromyotonia

  • Isaacs' Syndrome

  • Acquired Neuromyotonia

  • Continuous Muscle Fiber Activity Syndrome

  • Quantal Squander Syndrome

  • Isaacs-Mertens Syndrome

  • Ea Syndrome

  • Episodic Ataxia Syndrome

  • Isaac Syndrome

  • Isaac'S-Merten'S Syndrome

  • Isaac-Mertens Syndrome

  • Peripheral Nerve Hyperexcitability

  • Ea

  • Peripheral Nerve Hyperexcitability Syndrome

  • Ataxia, Episodic

  • Isaacs Neuromyotonia

  • Continuous Muscle Fibre Activity
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS19394 Ubr4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS15389 UBR4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25886 Ubr4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBR4 RGD RGD:1563121
Mus musculus UBR4 MGD MGI:1916366
Felis catus UBR4 VGNC VGNC:66787
Macaca mulatta UBR4 VGNC VGNC:79845
Bos taurus UBR4 VGNC VGNC:36618
Canis familiaris UBR4 VGNC VGNC:48091
Others UBR4 NCBI