Wdr77 - WD repeat domain 77 Gene

Also Known as p44/MEP50; 2610003I18Rik; 2610312E17Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70465

Summary

Predicted to enable methyl-CpG binding activity and nuclear receptor coactivator activity. Acts upstream of or within several processes, including negative regulation of epithelial cell proliferation involved in prostate gland development; regulation of transcription by RNA polymerase II; and secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development. Predicted to be located in Golgi apparatus and nucleus. Predicted to be part of methylosome. Predicted to be active in cytosol; nucleoplasm; and pole plasm. Is expressed in genitourinary system. Orthologous to human WDR77 (WD repeat domain 77). [provided by Alliance of Genome Resources, Apr 2022]

Wdr77 Products (1)

mRNA Protein Name
NM_027432.3 NP_081708.1 methylosome protein 50

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23055941 MGI
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
35197566 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
17032745 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18356297 MGI
acts upstream of or within negative regulation of epithelial cell proliferation involved in prostate gland development IMP
IMP: Inferred from mutant phenotype
17032745 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
18356297 MGI
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
35197566 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
17032745 MGI
acts upstream of or within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IMP
IMP: Inferred from mutant phenotype
17032745 MGI
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
35197566 MGI
Cellular Component GO Annotation Evidence References Source
part of Cul4B-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
35197566 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

methylosome protein 50

  • MEP-50

  • WD repeat-containing protein 77

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15798 WDR77 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20520 Wdr77 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27029 Wdr77 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wdr77 NCBI NCBI:79084