WDR77 - WD repeat domain 77 Gene

Also Known as p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79084

About WDR77

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,439,890-111,449,256 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 14.0), urinary bladder (RPKM 11.8) and 25 other tissues.

Summary

The protein encoded by this gene is an Androgen Receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate Cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in Cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

WDR77 Products (4)

mRNA Protein Name
NM_001317062.2 NP_001303991.1 methylosome protein 50 isoform 1
NM_001317063.2 NP_001303992.1 methylosome protein 50 isoform 3
NM_001317064.2 NP_001303993.1 methylosome protein 50 isoform 4
NM_024102.4 NP_077007.1 methylosome protein 50 isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables methyl-CpG binding IDA
IDA: Inferred from direct assay
25284789 GOA
enables nuclear receptor coactivator activity IGI
IGI: Inferred from genetic interaction
12972618 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11756452 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19188445 GOA
located in cytoplasm IGI
IGI: Inferred from genetic interaction
12972618 GOA
located in cytosol IDA
IDA: Inferred from direct assay
18984161 GOA
part of methylosome IDA
IDA: Inferred from direct assay
11756452 GOA
located in nucleus IDA
IDA: Inferred from direct assay
21081503 GOA
located in nucleus IGI
IGI: Inferred from genetic interaction
12972618 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR77 Protein Structure

WD40

WD40: WD domain, G-beta repeat (122 - 153)

WD40

WD40: WD domain, G-beta repeat (159 - 196)

WD40

WD40: WD domain, G-beta repeat (247 - 280)

  • 0
  • 100
  • 200
  • 300
  • 342 a.a.
Protein Preferred Names Protein Names

methylosome protein 50

  • WD repeat-containing protein 77

WDR77 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
WDR77 Q9BQA1 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Pull Down
11756452
Intra
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Anti Bait CoIP
26763441
Intra
WDR77 Q9BQA1 PRMT5 Homo sapiens O14744
Anti Bait CoIP
20951943
Intra
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
WDR77 Q9BQA1 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
WDR77 Q9BQA1 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
WDR77 Q9BQA1 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WDR77 Proteins

Cat. No. Product Name Accession Purity
HY-P71622 MEP50/WDR77 Protein, Human (His-SUMO) Q9BQA1 (M1-L312) ≥ 90%, as determined by reducing SDS-PAGE.

WDR77 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80931 WDR77 Antibody (YA655) WB, ICC/IF Human, Mouse, Rat
HY-P80931A WDR77 Antibody (YA655)(PBS only) WB, ICC/IF Human, Mouse, Rat
HY-P85589 WDR77 Antibody (YA5281) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Sarcomatoid Transitional Cell Carcinoma

  • Transitional Cell Carcinoma, Sarcomatoid

  • Transitional Spindle Cell Carcinoma

  • Transitional Cell Carcinoma, Spindle Cell
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15798 WDR77 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20520 Wdr77 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27029 Wdr77 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta WDR77 VGNC VGNC:79820
Mus musculus WDR77 MGD MGI:1917715
Felis catus WDR77 VGNC VGNC:67056
Rattus norvegicus WDR77 RGD RGD:1310479
Bos taurus WDR77 VGNC VGNC:36921
Others WDR77 NCBI