WDR77 - WD repeat domain 77 Gene

Homo sapiens

Also known as p44; MEP50; MEP-50; HKMT1069; Nbla10071; p44/Mep50

Gene ID: 79084 | Gene type: protein coding

About WDR77

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,439,890-111,449,256 (from NCBI)

This gene has 4 transcripts (splice variants), 214 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 14.0), urinary bladder (RPKM 11.8) and 25 other tissues.

Summary

The protein encoded by this gene is an Androgen Receptor coactivator that forms a complex with protein arginine methyltransferase 5, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. The encoded protein may be involved in the early stages of prostate Cancer, with most of the protein being nuclear-localized in benign cells but cytoplasmic in Cancer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

WDR77 Products(4)

mRNA	Protein	Name
NM_001317062.2	NP_001303991.1	methylosome protein 50 isoform 1
NM_001317063.2	NP_001303992.1	methylosome protein 50 isoform 3
NM_001317064.2	NP_001303993.1	methylosome protein 50 isoform 4
NM_024102.4	NP_077007.1	methylosome protein 50 isoform 2

WDR77 Protein Structure

WD40

0
100
200
300
342 a.a.

Protein Preferred Names

Protein Names

methylosome protein 50

WD repeat-containing protein 77

Recombinant WDR77 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71622	WDR77 Protein, Human (His-SUMO)	Q9BQA1 (1M-312L)	≥95%

Related Diseases

Diseases

Alias

Sarcomatoid Transitional Cell Carcinoma

Transitional Cell Carcinoma, Sarcomatoid	Transitional Spindle Cell Carcinoma
Transitional Cell Carcinoma, Spindle Cell

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15798	WDR77 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WDR77	VGNC	VGNC:79820
Mus musculus	WDR77	MGD	MGI:1917715
Felis catus	WDR77	VGNC	VGNC:67056
Rattus norvegicus	WDR77	RGD	RGD:1310479
Bos taurus	WDR77	VGNC	VGNC:36921
Others	WDR77	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.