Pnpt1 - polyribonucleotide nucleotidyltransferase 1 Gene

Also Known as Old35; PNPase; Pnptl1; 1200003F12Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 71701

Summary

Predicted to enable 3'-5'-exoribonuclease activity; RNA binding activity; and polyribonucleotide nucleotidyltransferase activity. Involved in mitochondrial mRNA catabolic process; mitochondrion morphogenesis; and regulation of cellular respiration. Located in mitochondrial intermembrane space. Is expressed in central nervous system and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 70 and combined Oxidative Phosphorylation deficiency 13. Orthologous to human PNPT1 (polyribonucleotide nucleotidyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pnpt1 Products (1)

mRNA Protein Name
NM_027869.2 NP_082145.1 polyribonucleotide nucleotidyltransferase 1, mitochondrial precursor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in mitochondrial mRNA catabolic process IMP
IMP: Inferred from mutant phenotype
20691904 MGI
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
16966381 MGI
involved in regulation of cellular respiration IMP
IMP: Inferred from mutant phenotype
16966381 MGI
Cellular Component GO Annotation Evidence References Source
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
16966381 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
16966381 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

polyribonucleotide nucleotidyltransferase 1, mitochondrial

  • 3'-5' RNA exonuclease OLD35

  • PNPase 1

  • PNPase old-35

  • polynucleotide phosphorylase 1

  • polynucleotide phosphorylase-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10801 PNPT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21028 Pnpt1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27545 Pnpt1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991956 ABB071 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnpt1 NCBI NCBI:87178